Utilisation of parametric methods to improve percentile-based estimates for the carcinogenic potency of nitrosamines.

Animals Carcinogenicity Tests / statistics & numerical data Carcinogens / toxicity Databases, Factual Nitrosamines / toxicity Risk Assessment / statistics & numerical data
Carcinogenicity N-Nitrosamine Percentile TD(50)

Journal

Regulatory toxicology and pharmacology : RTP
ISSN: 1096-0295
Titre abrégé: Regul Toxicol Pharmacol
Pays: Netherlands
ID NLM: 8214983

Informations de publication

Date de publication:
Apr 2021
Historique:
received: 03 09 2020
revised: 09 12 2020
accepted: 23 01 2021
pubmed: 9 2 2021
medline: 21 10 2021
entrez: 8 2 2021
Statut: ppublish

Résumé

N-Nitrosamines have recently been the subject of intense regulatory scrutiny, including the setting of low exposure limits (18 ng/day) (European Medicines Agency (EMA), 2020). This paper evaluates different methodologies to determine statistically robust bounds on the carcinogenic potency of chemical classes, using historic TD

Identifiants

DOI: 10.1016/j.yrtph.2021.104875 PMID: 33556416
pubmed: 33556416
pii: S0273-2300(21)00015-5
doi: 10.1016/j.yrtph.2021.104875
pii:
doi:

Substances chimiques

Carcinogens 0
Nitrosamines 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

104875

Informations de copyright

Copyright © 2021 Elsevier Inc. All rights reserved.

Auteurs

Robert Thomas (R)

Lhasa Limited, Granary Wharf House, Leeds, UK. Electronic address: rob.thomas@lhasalimited.org.

Andrew Thresher (A)

Lhasa Limited, Granary Wharf House, Leeds, UK.

David J Ponting (DJ)

Lhasa Limited, Granary Wharf House, Leeds, UK.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Utilisation of parametric methods to improve...
questionsmedicales.fr › Techniques d'investigation › Tests de toxicité › Tests de cancérogénicité › Utilisation of parametric methods to improve...
questionsmedicales.fr › Actions chimiques et utilisations › Actions toxiques › Noxas › Cancérogènes › Utilisation of parametric methods to improve...
questionsmedicales.fr › Sciences de l'information › Mémorisation et recherche des informations › Bases de données comme sujet › Bases de données factuelles › Utilisation of parametric methods to improve...
questionsmedicales.fr › Composés chimiques organiques › Composés nitrosés › Nitrosamines › Utilisation of parametric methods to improve...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Appréciation des risques › Utilisation of parametric methods to improve...