Genetic Therapy for Intervertebral Disc Degeneration.
CRISPR-Cas9
RNAi
genetic therapy
intervertebral disc degeneration
mTOR signaling
vector
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
04 Feb 2021
04 Feb 2021
Historique:
received:
05
12
2020
revised:
30
01
2021
accepted:
01
02
2021
entrez:
9
2
2021
pubmed:
10
2
2021
medline:
13
4
2021
Statut:
epublish
Résumé
Intervertebral disc (IVD) degeneration can cause chronic lower back pain (LBP), leading to disability. Despite significant advances in the treatment of discogenic LBP, the limitations of current treatments have sparked interest in biological approaches, including growth factor and stem cell injection, as new treatment options for patients with chronic LBP due to IVD degeneration (IVDD). Gene therapy represents exciting new possibilities for IVDD treatment, but treatment is still in its infancy. Literature searches were conducted using PubMed and Google Scholar to provide an overview of the principles and current state of gene therapy for IVDD. Gene transfer to degenerated disc cells in vitro and in animal models is reviewed. In addition, this review describes the use of gene silencing by RNA interference (RNAi) and gene editing by the clustered regularly interspaced short palindromic repeats (CRISPR) system, as well as the mammalian target of rapamycin (mTOR) signaling in vitro and in animal models. Significant technological advances in recent years have opened the door to a new generation of intradiscal gene therapy for the treatment of chronic discogenic LBP.
Identifiants
pubmed: 33557287
pii: ijms22041579
doi: 10.3390/ijms22041579
pmc: PMC7914740
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Korea Health Technology Research and Development Project, Ministry for Health and Welfare Affairs
ID : HR16C0002, HI20C0579
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