Elevated gut microbiome abundance of
Aged
Aging
/ metabolism
Bacteroidetes
/ isolation & purification
Body Composition
/ physiology
Clostridiales
/ isolation & purification
Diet
Female
Gastrointestinal Microbiome
/ physiology
Humans
Intra-Abdominal Fat
/ physiology
Italy
Male
Metabolome
/ physiology
Subcutaneous Fat, Abdominal
/ physiology
Microbiota
aging
diet
inflammaging
serum metabolome
visceral adipose tissue
Journal
Gut microbes
ISSN: 1949-0984
Titre abrégé: Gut Microbes
Pays: United States
ID NLM: 101495343
Informations de publication
Date de publication:
Historique:
entrez:
9
2
2021
pubmed:
10
2
2021
medline:
19
1
2022
Statut:
ppublish
Résumé
Aging is accompanied by physiological changes affecting body composition and functionality, including accumulation of fat mass at the expense of muscle mass, with effects upon morbidity and quality of life. The gut microbiome has recently emerged as a key environmental modifier of human health that can modulate healthy aging and possibly longevity. However, its associations with adiposity in old age are still poorly understood. Here we profiled the gut microbiota in a well-characterized cohort of 201 Italian elderly subjects from the NU-AGE study, by 16S rRNA amplicon sequencing. We then tested for association with body composition from dual-energy X-ray absorptiometry (DXA), with a focus on visceral and subcutaneous adipose tissue. Dietary patterns, serum metabolome and other health-related parameters were also assessed. This study identified distinct compositional structures of the elderly gut microbiota associated with DXA parameters, diet, metabolic profiles and cardio-metabolic risk factors.
Identifiants
pubmed: 33557667
doi: 10.1080/19490976.2021.1880221
pmc: PMC7889099
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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