Perfusion imaging-based tissue-level collaterals predict ischemic lesion net water uptake in patients with acute ischemic stroke and large vessel occlusion.
Acute Disease
Aged
Aged, 80 and over
Brain
/ blood supply
Collateral Circulation
Female
Humans
Ischemic Stroke
/ diagnostic imaging
Logistic Models
Magnetic Resonance Imaging
Male
Middle Aged
Odds Ratio
Perfusion Imaging
/ methods
Retrospective Studies
Thrombectomy
Tissue Plasminogen Activator
/ therapeutic use
Tomography, X-Ray Computed
Collateral circulation
ischemic edema
net water uptake
perfusion imaging
tissue perfusion
Journal
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
ISSN: 1559-7016
Titre abrégé: J Cereb Blood Flow Metab
Pays: United States
ID NLM: 8112566
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
pubmed:
10
2
2021
medline:
25
8
2021
entrez:
9
2
2021
Statut:
ppublish
Résumé
Ischemic lesion Net Water Uptake (NWU) quantifies cerebral edema formation and likely correlates with the microvascular perfusion status of patients with acute ischemic stroke due to large vessel occlusion (AIS-LVO). We hypothesized that favorable tissue-level collaterals (TLC) predict less NWU and good functional outcomes. We performed a retrospective multicenter analysis of AIS-LVO patients who underwent thrombectomy triage. TLC were measured on cerebral perfusion studies using the hypoperfusion intensity ratio (HIR; volume ratio of brain tissue with [Tmax > 10 sec/Tmax > 6 sec]); favorable TLC were regarded as HIR
Identifiants
pubmed: 33557694
doi: 10.1177/0271678X21992200
pmc: PMC8327120
doi:
Substances chimiques
Tissue Plasminogen Activator
EC 3.4.21.68
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2067-2075Références
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