Static compliance of the respiratory system in COVID-19 related ARDS: an international multicenter study.
ICU
Mechanical ventilation
Mortality
PEEP
Plateau pressure
Respiratory mechanics
SARS-COV-2
Journal
Critical care (London, England)
ISSN: 1466-609X
Titre abrégé: Crit Care
Pays: England
ID NLM: 9801902
Informations de publication
Date de publication:
08 02 2021
08 02 2021
Historique:
received:
24
09
2020
accepted:
11
12
2020
entrez:
9
2
2021
pubmed:
10
2
2021
medline:
20
2
2021
Statut:
epublish
Résumé
Controversies exist on the nature of COVID-19 related acute respiratory distress syndrome (ARDS) in particular on the static compliance of the respiratory system (Crs). We aimed to analyze the association of Crs with outcome in COVID-19-associated ARDS, to ascertain its determinants and to describe its evolution at day-14. In this observational multicenter cohort of patients with moderate to severe Covid-19 ARDS, Crs was measured at day-1 and day-14. Association between Crs or Crs/ideal body weight (IBW) and breathing without assistance at day-28 was analyzed with multivariable logistic regression. Determinants were ascertained by multivariable linear regression. Day-14 Crs was compared to day-1 Crs with paired t-test in patients still under controlled mechanical ventilation. The mean Crs in 372 patients was 37.6 ± 13 mL/cmH In a large multicenter cohort of moderate to severe COVID-19 ARDS, mean Crs was decreased below 40 mL/cmH
Sections du résumé
BACKGROUND
Controversies exist on the nature of COVID-19 related acute respiratory distress syndrome (ARDS) in particular on the static compliance of the respiratory system (Crs). We aimed to analyze the association of Crs with outcome in COVID-19-associated ARDS, to ascertain its determinants and to describe its evolution at day-14.
METHODS
In this observational multicenter cohort of patients with moderate to severe Covid-19 ARDS, Crs was measured at day-1 and day-14. Association between Crs or Crs/ideal body weight (IBW) and breathing without assistance at day-28 was analyzed with multivariable logistic regression. Determinants were ascertained by multivariable linear regression. Day-14 Crs was compared to day-1 Crs with paired t-test in patients still under controlled mechanical ventilation.
RESULTS
The mean Crs in 372 patients was 37.6 ± 13 mL/cmH
CONCLUSION
In a large multicenter cohort of moderate to severe COVID-19 ARDS, mean Crs was decreased below 40 mL/cmH
Identifiants
pubmed: 33557868
doi: 10.1186/s13054-020-03433-0
pii: 10.1186/s13054-020-03433-0
pmc: PMC7868865
doi:
Types de publication
Journal Article
Multicenter Study
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
52Investigateurs
Benoit Vandenbunder
(B)
Stephan Ehrmann
(S)
Michael Piagnerelli
(M)
Bertrand Sauneuf
(B)
Nicolas Serck
(N)
Thibaud Soumagne
(T)
Julien Textoris
(J)
Christophe Vinsonneau
(C)
Nadia Aissaoui
(N)
Gauthier Blonz
(G)
Giuseppe Carbutti
(G)
Romain Courcelle
(R)
Alain D'hondt
(A)
Stephane Gaudry
(S)
Julien Higny
(J)
Geoffroy Horlait
(G)
Sami Hraiech
(S)
Laurent Lefebvre
(L)
Francois Lejeune
(F)
Andre Ly
(A)
Jean-Baptiste Lascarrou
(JB)
David Grimaldi
(D)
Patrick Biston
(P)
Gwenhael Colin
(G)
Oriane de Maere
(O)
Nathan Ebstein
(N)
Frederic Foret
(F)
Thibault Helbert
(T)
Jean-Baptiste Mesland
(JB)
Celine Monard
(C)
Nicolas Mongardon
(N)
Gregoire Ottavy
(G)
Thomas Pasau
(T)
Gael Piton
(G)
Zoe Pletschette
(Z)
Ester Ponzetto
(E)
Caroline Sejourne
(C)
Piotr Szychowiak
(P)
Xavier Souloy
(X)
Aude Sylvestre
(A)
Nicolas Tartrat
(N)
Cedric Vanbrussel
(C)
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