Regulation of the Wound Healing Response during Aging.


Journal

The Journal of investigative dermatology
ISSN: 1523-1747
Titre abrégé: J Invest Dermatol
Pays: United States
ID NLM: 0426720

Informations de publication

Date de publication:
04 2021
Historique:
received: 02 10 2020
revised: 30 10 2020
accepted: 16 11 2020
pubmed: 10 2 2021
medline: 28 10 2021
entrez: 9 2 2021
Statut: ppublish

Résumé

An effective healing response is critical to promote and ensure healthy aging. Major discoveries in both fields-repair and aging-have led to a better understanding of the mechanisms regulating the healing response and of the complexity of the aging process. It will now be important to translate and connect those findings to improve our insights into the decline of regeneration in the elderly. Furthermore, we need to understand how this process can be stalled to maintain and promote tissue resilience. Furthermore, it remains to be explored how the findings in model organisms are conserved in human wounds and how these findings might be translated into the clinic.

Identifiants

pubmed: 33558058
pii: S0022-202X(20)32360-5
doi: 10.1016/j.jid.2020.11.014
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

1063-1070

Informations de copyright

Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.

Auteurs

Xiaolei Ding (X)

Department of Dermatology, University of Cologne, Cologne, Germany.

Parisa Kakanj (P)

Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany; Cluster of Excellence Cellular Stress Responses in Aging-associated Diseases (CECAD), University of Cologne, Cologne, Germany; Institute for Genetics, University of Cologne, Cologne, Germany; Director's Research Unit, European Molecular Biology Laboratory, Heidelberg, Germany.

Maria Leptin (M)

Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany; Cluster of Excellence Cellular Stress Responses in Aging-associated Diseases (CECAD), University of Cologne, Cologne, Germany; Institute for Genetics, University of Cologne, Cologne, Germany; Director's Research Unit, European Molecular Biology Laboratory, Heidelberg, Germany.

Sabine A Eming (SA)

Department of Dermatology, University of Cologne, Cologne, Germany; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany; Cluster of Excellence Cellular Stress Responses in Aging-associated Diseases (CECAD), University of Cologne, Cologne, Germany; Institute of Zoology, Developmental Biology Unit, University of Cologne, Cologne, Germany. Electronic address: sabine.eming@uni-koeln.de.

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Classifications MeSH