Placental genomic risk scores and early neurodevelopmental outcomes.
developmental trajectories
genomic risk scores
neurodevelopment
placental gene expression
schizophrenia
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
16 02 2021
16 02 2021
Historique:
entrez:
9
2
2021
pubmed:
10
2
2021
medline:
23
7
2021
Statut:
ppublish
Résumé
Tracing the early paths leading to developmental disorders is critical for prevention. In previous work, we detected an interaction between genomic risk scores for schizophrenia (GRSs) and early-life complications (ELCs), so that the liability of the disorder explained by genomic risk was higher in the presence of a history of ELCs, compared with its absence. This interaction was specifically driven by loci harboring genes highly expressed in placentae from normal and complicated pregnancies [G. Ursini et al.,
Identifiants
pubmed: 33558239
pii: 2019789118
doi: 10.1073/pnas.2019789118
pmc: PMC7896349
pii:
doi:
Banques de données
ClinicalTrials.gov
['NCT00001486']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIMH NIH HHS
ID : P50 MH094268
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA MH002942
Pays : United States
Informations de copyright
Copyright © 2021 the Author(s). Published by PNAS.
Déclaration de conflit d'intérêts
The authors declare no competing interest.
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