Prostaglandin E
epithelial barrier
epithelial differentiation
inflammatory bowel disease
macrophages
prostaglandins
Journal
Gut
ISSN: 1468-3288
Titre abrégé: Gut
Pays: England
ID NLM: 2985108R
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
received:
09
06
2020
revised:
16
12
2020
accepted:
20
12
2020
pubmed:
10
2
2021
medline:
13
1
2022
entrez:
9
2
2021
Statut:
ppublish
Résumé
Dysfunctional resolution of intestinal inflammation and altered mucosal healing are essential features in the pathogenesis of inflammatory bowel disease (IBD). Intestinal macrophages are vital in the process of inflammation resolution, but the mechanisms underlying their mucosal healing capacity remain elusive. We investigated the role of the prostaglandin E Here, we describe a subset of PTGER4-expressing intestinal macrophages with mucosal healing properties both in humans and mice. Csf1r-iCre Ptger4 PTGER4
Identifiants
pubmed: 33558271
pii: gutjnl-2020-322146
doi: 10.1136/gutjnl-2020-322146
doi:
Substances chimiques
Chemokine CXCL1
0
Cxcl1 protein, mouse
0
Ptger4 protein, mouse
0
Receptors, Prostaglandin E, EP4 Subtype
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2249-2260Informations de copyright
© Author(s) (or their employer(s)) 2021. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.