Chemokines and chemokine receptors during COVID-19 infection.
AECs, airway epithelial cells
AP-1, Activator Protein 1
ARDS
ARDS, acute respiratory disease syndrome
BALF, bronchial alveolar lavage fluid
CAP, community acquired pneumonia
COVID-19
CRS, cytokine releasing syndrome
Chemokine Receptors
Chemokines
DCs, dendritic cells
ECM, extracellular matrix
GAGs, glycosaminoglycans
HIV, human immunodeficiency virus
HRSV, human respiratory syncytial virus
IFN, interferon
IMM, inflammatory monocytes and macrophages
IP-10, IFN-γ-inducible protein 10
IRF, interferon regulatory factor
Immunity
MERS-CoV, Middle East respiratory syndrome coronavirus
NETs, neutrophil extracellular traps
NF-κB, Nuclear Factor kappa-light-chain-enhancer of activated B cells
NK cells, natural killer cells
PBMCs, peripheral blood mononuclear cells
PRR, pattern recognition receptors
RSV, rous sarcoma virus
SARS-CoV, severe acute respiratory syndrome coronavirus
SARS-CoV-2
TLR, toll like receptor
TRIF, TIR-domain-containing adapter-inducing interferon-β
Journal
Computational and structural biotechnology journal
ISSN: 2001-0370
Titre abrégé: Comput Struct Biotechnol J
Pays: Netherlands
ID NLM: 101585369
Informations de publication
Date de publication:
2021
2021
Historique:
received:
12
12
2020
revised:
19
01
2021
accepted:
20
01
2021
entrez:
9
2
2021
pubmed:
10
2
2021
medline:
10
2
2021
Statut:
ppublish
Résumé
Chemokines are crucial inflammatory mediators needed during an immune response to clear pathogens. However, their excessive release is the main cause of hyperinflammation. In the recent COVID-19 outbreak, chemokines may be the direct cause of acute respiratory disease syndrome, a major complication leading to death in about 40% of severe cases. Several clinical investigations revealed that chemokines are directly involved in the different stages of SARS-CoV-2 infection. Here, we review the role of chemokines and their receptors in COVID-19 pathogenesis to better understand the disease immunopathology which may aid in developing possible therapeutic targets for the infection.
Identifiants
pubmed: 33558827
doi: 10.1016/j.csbj.2021.01.034
pii: S2001-0370(21)00038-6
pmc: PMC7859556
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
976-988Informations de copyright
© 2021 The Author(s).
Déclaration de conflit d'intérêts
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Références
Cancer Res. 2006 Apr 15;66(8):4198-207
pubmed: 16618742
N Engl J Med. 2003 May 15;348(20):1977-85
pubmed: 12671062
J Immunol. 1999 Aug 15;163(4):2193-201
pubmed: 10438961
J Virol. 2007 Aug;81(16):8692-706
pubmed: 17537853
J Clin Invest. 2020 May 1;130(5):2620-2629
pubmed: 32217835
PLoS Pathog. 2011 Jul;7(7):e1002098
pubmed: 21814510
J Immunol. 1994 Dec 1;153(11):4969-77
pubmed: 7525719
Am J Respir Crit Care Med. 2005 Apr 15;171(8):850-7
pubmed: 15657466
Cell. 2008 Apr 18;133(2):235-49
pubmed: 18423196
J Exp Med. 1998 Jun 15;187(12):2009-21
pubmed: 9625760
Int Immunopharmacol. 2010 Feb;10(2):259-63
pubmed: 19909826
Nat Rev Immunol. 2002 Feb;2(2):106-15
pubmed: 11910892
N Engl J Med. 2020 Oct 15;383(16):1522-1534
pubmed: 32558485
Hum Immunol. 2005 Nov;66(11):1146-54
pubmed: 16571415
Science. 1996 Jun 28;272(5270):1955-8
pubmed: 8658171
J Biol Chem. 1998 Apr 24;273(17):10095-8
pubmed: 9553055
Lancet Respir Med. 2020 Apr;8(4):420-422
pubmed: 32085846
PLoS Pathog. 2008 Dec;4(12):e1000240
pubmed: 19079579
Ther Adv Respir Dis. 2020 Jan-Dec;14:1753466620933508
pubmed: 32539627
Nat Rev Immunol. 2011 Oct 10;11(11):762-74
pubmed: 21984070
Cell Host Microbe. 2016 Feb 10;19(2):181-93
pubmed: 26867177
Eur J Immunol. 1997 Oct;27(10):2484-9
pubmed: 9368600
Int J Mol Med. 2005 Feb;15(2):323-7
pubmed: 15647850
JAMA. 2020 Apr 28;323(16):1574-1581
pubmed: 32250385
Clin Exp Immunol. 1998 Apr;112(1):92-9
pubmed: 9566795
Nat Immunol. 2019 Jan;20(1):97-108
pubmed: 30510223
Nat Med. 2020 Apr;26(4):453-455
pubmed: 32284614
J Exp Med. 1998 Jan 5;187(1):1-14
pubmed: 9419206
N Engl J Med. 2020 Feb 20;382(8):727-733
pubmed: 31978945
J Clin Invest. 2006 Mar;116(3):695-702
pubmed: 16485040
Clin Ther. 2006 Mar;28(3):319-31
pubmed: 16750447
J Virol. 2001 Jul;75(14):6450-9
pubmed: 11413312
Proc Natl Acad Sci U S A. 2004 Aug 10;101(32):11791-6
pubmed: 15282370
Nat Med. 2020 Jun;26(6):842-844
pubmed: 32398875
J Infect Dis. 2014 May 1;209(9):1331-42
pubmed: 24065148
Am J Pathol. 2000 Jun;156(6):1951-9
pubmed: 10854218
Mol Cell Biol. 1999 Feb;19(2):959-66
pubmed: 9891032
Am Rev Respir Dis. 1986 Feb;133(2):218-25
pubmed: 3004270
Science. 1995 Dec 15;270(5243):1811-5
pubmed: 8525373
N Engl J Med. 2003 Jul 31;349(5):507-8
pubmed: 12890854
Virol J. 2006 Mar 29;3:17
pubmed: 16571117
J Immunol. 2008 Feb 15;180(4):2641-9
pubmed: 18250476
JCI Insight. 2017 Apr 6;2(7):e91868
pubmed: 28405622
J Allergy Clin Immunol. 2020 Jul;146(1):119-127.e4
pubmed: 32360286
PLoS One. 2012;7(2):e32366
pubmed: 22389696
Nat Commun. 2020 Jul 6;11(1):3434
pubmed: 32632085
Nat Med. 2005 Nov;11(11):1180-7
pubmed: 16208318
Cell. 2004 Aug 20;118(4):453-64
pubmed: 15315758
Antiviral Res. 2016 Jul;131:148-55
pubmed: 27155352
Trends Microbiol. 2003 Aug;11(8):383-91
pubmed: 12915096
J Immunol. 2009 Oct 1;183(7):4378-84
pubmed: 19734208
J Virol. 2005 Jun;79(12):7819-26
pubmed: 15919935
Autoimmun Rev. 2020 Jul;19(7):102567
pubmed: 32376392
BMC Infect Dis. 2004 Sep 09;4:34
pubmed: 15357874
Curr Opin Allergy Clin Immunol. 2003 Dec;3(6):467-73
pubmed: 14612671
Am J Respir Crit Care Med. 1996 Sep;154(3 Pt 1):602-11
pubmed: 8810593
J Biol Chem. 1996 Sep 13;271(37):22878-84
pubmed: 8798467
Science. 2020 May 1;368(6490):473-474
pubmed: 32303591
J Immunol. 2008 Feb 15;180(4):2562-72
pubmed: 18250467
Cytokine. 2020 Feb;126:154895
pubmed: 31706200
Emerg Microbes Infect. 2020 Dec;9(1):761-770
pubmed: 32228226
J Biol Chem. 2001 Jun 29;276(26):23382-90
pubmed: 11303025
Front Immunol. 2017 Oct 16;8:1274
pubmed: 29085362
Proc Natl Acad Sci U S A. 2014 Mar 11;111(10):3799-804
pubmed: 24572573
Am J Respir Crit Care Med. 2020 Dec 1;202(11):1509-1519
pubmed: 32866033
Virus Res. 2005 Jan;107(1):93-101
pubmed: 15567038
Chest. 2010 Apr;137(4):812-22
pubmed: 19837822
Crit Care Explor. 2020 Apr 29;2(4):e0111
pubmed: 32426753
J Med Virol. 2015 Feb;87(2):330-7
pubmed: 25132248
J Appl Physiol (1985). 2007 Aug;103(2):594-9
pubmed: 17556491
Viral Immunol. 2012 Aug;25(4):333-7
pubmed: 22788418
Arch Pathol Lab Med. 2016 Apr;140(4):345-50
pubmed: 27028393
J Interferon Cytokine Res. 2011 May;31(5):409-13
pubmed: 21235417
J Gen Virol. 2016 Feb;97(2):344-355
pubmed: 26602089
PLoS One. 2010 Nov 16;5(11):e13889
pubmed: 21124967
J Virol. 2014 Jan;88(2):913-24
pubmed: 24198408
Signal Transduct Target Ther. 2020 Jun 19;5(1):100
pubmed: 32561706
Front Immunol. 2013 Jan 24;4:1
pubmed: 23355837
JCI Insight. 2020 Jun 18;5(12):
pubmed: 32427582
Sci Immunol. 2021 Jan 8;6(55):
pubmed: 33419791
Nat Rev Immunol. 2003 Jan;3(1):36-50
pubmed: 12511874
Virology. 2006 Jan 5;344(1):119-30
pubmed: 16364743
Eur J Pharmacol. 2002 Sep 6;451(1):1-10
pubmed: 12223222
Cytokine Growth Factor Rev. 1997 Sep;8(3):207-19
pubmed: 9462486
J Virol. 2001 Jan;75(2):878-90
pubmed: 11134301
Biochem Biophys Res Commun. 2003 Nov 28;311(4):870-6
pubmed: 14623261
J Clin Invest. 2001 Aug;108(4):547-56
pubmed: 11518728
Front Immunol. 2018 Jan 12;8:1981
pubmed: 29375583
Hum Pathol. 2003 Aug;34(8):743-8
pubmed: 14506633
Hum Immunol. 2017 Nov;78(11-12):710-717
pubmed: 28987960
Am J Respir Crit Care Med. 1996 Sep;154(3 Pt 1):594-601
pubmed: 8810592
Einstein (Sao Paulo). 2015 Jul-Sep;13(3):469-73
pubmed: 26466066
Am J Respir Crit Care Med. 2013 Jan 1;187(1):65-77
pubmed: 23144331
Blood. 2005 Oct 1;106(7):2366-74
pubmed: 15860669
Front Immunol. 2015 Jan 30;6:12
pubmed: 25688243
J Immunol. 1993 Apr 15;150(8 Pt 1):3448-58
pubmed: 7682242
Nat Rev Immunol. 2020 Jun;20(6):355-362
pubmed: 32376901
Semin Immunopathol. 2017 Jul;39(5):529-539
pubmed: 28466096
Infect Genet Evol. 2020 Nov;85:104512
pubmed: 32858232
Science. 1995 Sep 15;269(5230):1583-5
pubmed: 7667639
PLoS Pathog. 2021 Jul 16;17(7):e1009761
pubmed: 34270631
Signal Transduct Target Ther. 2020 May 29;5(1):84
pubmed: 32467561
Postgrad Med J. 2021 Jun;97(1148):391-398
pubmed: 33008960
J Immunol. 2001 Oct 15;167(8):4635-43
pubmed: 11591793
J Microbiol Immunol Infect. 2020 Jun;53(3):368-370
pubmed: 32205092
Clin Immunol. 2020 Jun;215:108448
pubmed: 32353634
J Virol. 2006 Mar;80(6):2684-93
pubmed: 16501078
J Leukoc Biol. 2003 Sep;74(3):331-43
pubmed: 12949236
Am J Gastroenterol. 2002 Nov;97(11):2861-70
pubmed: 12425561
Curr Opin Immunol. 2005 Aug;17(4):404-10
pubmed: 15950449
JAMA. 2003 Jul 16;290(3):374-80
pubmed: 12865379
Cell Mol Immunol. 2020 May;17(5):533-535
pubmed: 32203188
Front Immunol. 2020 Jun 16;11:1441
pubmed: 32612615
J Leukoc Biol. 2014 Dec;96(6):1055-63
pubmed: 25157027
Cell. 2020 Jun 25;181(7):1475-1488.e12
pubmed: 32479746
J Immunol. 2003 Mar 15;170(6):3273-8
pubmed: 12626586
Life Sci. 2020 Sep 15;257:118102
pubmed: 32687918
J Exp Med. 2003 Apr 7;197(7):885-98
pubmed: 12682109
Curr Pharmacol Rep. 2016 Feb;2(1):1-10
pubmed: 27088072
Gut. 2017 Jan;66(1):157-167
pubmed: 26452628
Nat Commun. 2020 Oct 8;11(1):5086
pubmed: 33033248
Cell Mol Life Sci. 2004 Aug;61(16):2100-12
pubmed: 15316659
Clin Chim Acta. 2020 Nov;510:60-61
pubmed: 32653483
J Immunol. 1999 Apr 15;162(8):4928-37
pubmed: 10202039
Blood. 1991 Aug 15;78(4):1112-6
pubmed: 1868242
Retrovirology. 2015 Jan 22;12:4
pubmed: 25608886
Lancet. 2020 Feb 15;395(10223):497-506
pubmed: 31986264
Biomolecules. 2015 Jul 01;5(3):1386-98
pubmed: 26140537
J Infect Dis. 2005 Apr 15;191(8):1225-32
pubmed: 15776367
Eur J Med Chem. 2016 May 23;114:65-78
pubmed: 26974376
J Virol. 2001 Jul;75(13):6095-106
pubmed: 11390611
J Immunol. 2011 Jan 1;186(1):508-15
pubmed: 21098218
Cytokine Growth Factor Rev. 2008 Apr;19(2):121-32
pubmed: 18321765
Int J Mol Sci. 2019 Jun 06;20(11):
pubmed: 31174392
J Exp Med. 1988 May 1;167(5):1547-59
pubmed: 2835419
J Clin Invest. 2020 Dec 1;130(12):6588-6599
pubmed: 32841212
J Infect Dis. 2016 Mar 15;213(6):904-14
pubmed: 26203058
Virology. 2014 Apr;454-455:197-205
pubmed: 24725946
J Immunol. 1999 Mar 15;162(6):3549-58
pubmed: 10092813
Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1885-90
pubmed: 12571364
Expert Opin Investig Drugs. 2016 Dec;25(12):1377-1392
pubmed: 27791451
Cell Host Microbe. 2020 Jun 10;27(6):883-890.e2
pubmed: 32407669
Am J Respir Crit Care Med. 1995 Nov;152(5 Pt 1):1549-54
pubmed: 7582292
J Virol. 2005 Nov;79(21):13800-5
pubmed: 16227300
Cell. 2020 Sep 17;182(6):1401-1418.e18
pubmed: 32810439
JCI Insight. 2020 Jun 4;5(11):
pubmed: 32329756
Natl Sci Rev. 2020 Jun;7(6):998-1002
pubmed: 34676125
J Virol. 2010 Feb;84(3):1289-301
pubmed: 19906920
Curr Opin Virol. 2011 Dec;1(6):463-75
pubmed: 22440910
Cell. 2020 May 28;181(5):1036-1045.e9
pubmed: 32416070
Immunity. 2014 Oct 16;41(4):633-45
pubmed: 25308332
Cytokine Growth Factor Rev. 2020 Jun;53:25-32
pubmed: 32446778
Nat Med. 2004 Sep;10(9):927-34
pubmed: 15311275
Am J Physiol Lung Cell Mol Physiol. 2000 Jul;279(1):L25-35
pubmed: 10893199
Clin Infect Dis. 2020 Sep 12;71(6):1400-1409
pubmed: 32270184
J Med Chem. 2010 Jan 28;53(2):521-38
pubmed: 19785437
J Immunol. 2010 Jun 1;184(11):6114-23
pubmed: 20427772
Blood. 2001 Jan 15;97(2):367-75
pubmed: 11154210
Eur J Immunol. 1996 Feb;26(2):315-9
pubmed: 8617297
Front Immunol. 2020 Sep 02;11:2132
pubmed: 32983172
Nature. 1996 Aug 22;382(6593):722-5
pubmed: 8751444
Nat Immunol. 2020 Oct;21(10):1146-1151
pubmed: 32855555
J Pharmacol Exp Ther. 2007 Aug;322(2):486-93
pubmed: 17496165
J Clin Invest. 2000 Apr;105(7):985-93
pubmed: 10749577
Sci Rep. 2016 Jan 04;6:18424
pubmed: 26725683
Nat Rev Immunol. 2020 Jun;20(6):363-374
pubmed: 32346093
J Immunol. 2000 Apr 15;164(8):4048-54
pubmed: 10754297
J Immunol. 2004 Dec 15;173(12):7602-14
pubmed: 15585888
J Infect Dis. 2020 Aug 4;222(5):746-754
pubmed: 32563194
BMJ. 2020 Apr 21;369:m1443
pubmed: 32317267
Nat Med. 2004 Dec;10(12 Suppl):S88-97
pubmed: 15577937
Lancet. 2003 May 24;361(9371):1773-8
pubmed: 12781536
Am J Respir Crit Care Med. 2009 May 1;179(9):799-805
pubmed: 19218194
Am J Respir Crit Care Med. 1994 Jul;150(1):113-22
pubmed: 8025736
Clin Exp Immunol. 2004 Apr;136(1):95-103
pubmed: 15030519
FASEB J. 1997 Aug;11(10):765-74
pubmed: 9271361
J Immunol. 2004 Sep 15;173(6):4030-9
pubmed: 15356152
Microcirculation. 2003 Jun;10(3-4):273-88
pubmed: 12851645
J Clin Virol. 2017 May;90:32-37
pubmed: 28334685
Clin Immunol. 2008 Jul;128(1):85-93
pubmed: 18439876
J Clin Invest. 2004 Jul;114(2):291-9
pubmed: 15254596
JCI Insight. 2020 Jul 9;5(13):
pubmed: 32501293
Front Immunol. 2020 Aug 28;11:2145
pubmed: 32983174
Cell Res. 2013 Apr;23(4):577-80
pubmed: 23419516