Tissue factor expression and tumor-infiltrating T lymphocytes in ovarian carcinomas and their association with venous thromboembolism.
Adenocarcinoma, Clear Cell
/ complications
Aged
CD8-Positive T-Lymphocytes
/ metabolism
Carcinoma, Endometrioid
/ complications
Female
Humans
Lymphocytes, Tumor-Infiltrating
/ metabolism
Membrane Glycoproteins
/ metabolism
Middle Aged
Ovarian Neoplasms
/ metabolism
P-Selectin
/ metabolism
Thromboplastin
/ metabolism
Thrombosis
Venous Thromboembolism
/ complications
P-selectin
cancer-associated thrombosis
ovarian cancer
pathology
podoplanin
tissue factor
tumor-infiltrating lymphocyte
venous thromboembolism
Journal
Pathology international
ISSN: 1440-1827
Titre abrégé: Pathol Int
Pays: Australia
ID NLM: 9431380
Informations de publication
Date de publication:
Apr 2021
Apr 2021
Historique:
received:
09
09
2020
accepted:
15
01
2021
pubmed:
10
2
2021
medline:
19
1
2022
entrez:
9
2
2021
Statut:
ppublish
Résumé
Ovarian cancer is a known risk factor of venous thromboembolism (VTE). Thrombogenic factor expression and lymphocytic infiltrate have been reported in endometriosis and ovarian cancers. We reviewed 30 cases of ovarian carcinomas (high grade serous carcinoma, 10; endometrioid carcinoma, 10; clear cell carcinoma (CCC), 10) and 16 endometriotic lesions. We immunohistochemically investigated the expressions of tissue factor (TF), podoplanin, P-selectin, and number of CD4 and CD8 positive lymphocytes in cancer tissue and endometriotic lesions, along with their relationship with VTE. The expression of TF was higher in CCC. The TF expression and the number of CD8 positive cells were higher in cancer tissues with VTE than in those without VTE. The podoplanin or P-selectin expression did not differ among histological types or between cases with and without VTE. Our results demonstrated a high TF expression and intraepithelial CD8 cells in CCC, which were associated with VTE. The results suggest that infiltrating lymphocytes may affect TF expression that, in turn, influences VTE.
Substances chimiques
Membrane Glycoproteins
0
P-Selectin
0
PDPN protein, human
0
Thromboplastin
9035-58-9
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
261-266Subventions
Organisme : Japan Society for the Promotion of Science
ID : 15K09963
Organisme : Japan Society for the Promotion of Science
ID : 18K15083
Organisme : Japan Society for the Promotion of Science
ID : 19K07437
Organisme : Japan Society for the Promotion of Science
ID : 20K08085
Organisme : Grants-in-Aid for Scientific Research
Informations de copyright
© 2021 Japanese Society of Pathology and John Wiley & Sons Australia, Ltd.
Références
Cohen A, Lim CS, Davies AH. Venous thromboembolism in gynecological malignancy. Int J Gynecol Cancer 2017; 27: 1970-8.
Kato N. Pathology of clear cell carcinoma of the ovary: A basic view based on cultured cells and modern view from comprehensive approaches. Pathol Int 2020; 70: 591-601.
Grover SP, Mackman N. Tissue factor: An essential mediator of hemostasis and trigger of thrombosis. Arterioscler Thromb Vasc Biol 2018; 38: 709-25.
Uno K, Homma S, Satoh T et al. Tissue factor expression as a possible determinant of thromboembolism in ovarian cancer. Br J Cancer 2007; 96: 290-5.
Krikun G, Schatz F, Taylor H, Lockwood CJ. Endometriosis and tissue factor. Ann NY Acad Sci 2008; 1127: 101-5.
Jander S, Sitzer M, Wendt A et al. Expression of tissue factor in high-grade carotid artery stenosis: Association with plaque destabilization. Stroke 2001; 32: 850-4.
Chen L, Lu Y, Chu Y, Xie J, Ding W, Wang F. Tissue factor expression in rheumatoid synovium: A potential role in pannus invasion of rheumatoid arthritis. Acta Histochem 2013; 115: 692-7.
Santoiemma PP, Powell DJ Jr. Tumor infiltrating lymphocytes in ovarian cancer. Cancer Biol Ther 2015; 16: 807-20.
Sato E, Olson SH, Ahn J et al. Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer. Proc Natl Acad Sci U S A 2005; 102: 18538-43.
Mir Seyed Nazari P, Riedl J, Pabinger I, Ay C. The role of podoplanin in cancer-associated thrombosis. Thromb Res 2018; 164: S34-9.
Shamay Y, Elkabets M, Li H et al. P-selectin is a nanotherapeutic delivery target in the tumor microenvironment. Sci Transl Med 2016; 8: 345ra87.
Riedl J, Ay C. Venous thromboembolism in brain tumors: Risk factors, molecular mechanisms, and clinical challenges. Semin Thromb Hemost 2019; 45: 334-41.
Kurman RJ, Carcangiu ML, Herrington CS, Young RH. World Health Organization Classification of Tumours of Female Reproductive Organs, 4th edn. Lyon: International Agency for Research on Cancer, 2014.
Aman M, Ohishi Y, Imamura H et al. Expression of protease-activated receptor-2 (PAR-2) is related to advanced clinical stage and adverse prognosis in ovarian clear cell carcinoma. Hum Pathol 2017; 64: 156-63.
Abu Saadeh F, Norris L, O'Toole S et al. Tumour expresion of tissue factor and tissue factor pathway inhibitor in ovarian cancer - relationship with venous thrombosis risk. Thromb Res 2013; 132: 627-34.
Kato J, Okamoto T, Motoyama H et al. Interferon-gamma-mediated tissue factor expression contributes to T-cell-mediated hepatitis through induction of hypercoagulation in mice. Hepatology 2013; 57: 362-72.
Freeman ML, Panigrahi S, Chen B et al. CD8+ T-cell-derived tumor necrosis factor can induce tissue factor expression on monocytes. J Infect Dis 2019; 220: 73-7.
Yang Y, Stang A, Schweickert PG et al. Thrombin signaling promotes pancreatic adenocarcinoma through PAR-1-dependent immune evasion. Cancer Res 2019; 79: 3417-30.
Oe S, Hasegawa K, Nagase S, Kato R, Torii Y, Udagawa Y. Expression of podoplanin in epithelial ovarian carcinomas and its potential as a marker for clear cell adenocarcinoma. Int J Gynecol Pathol 2010; 29: 405-10.
Ay C, Simanek R, Vormittag R et al. High plasma levels of soluble P-selectin are predictive of venous thromboembolism in cancer patients: Results from the Vienna Cancer and Thrombosis Study (CATS). Blood 2008; 112: 2703-8.