Trichodysplasia spinulosa: a comprehensive review of the disease and its treatment.
Journal
Journal of the European Academy of Dermatology and Venereology : JEADV
ISSN: 1468-3083
Titre abrégé: J Eur Acad Dermatol Venereol
Pays: England
ID NLM: 9216037
Informations de publication
Date de publication:
May 2021
May 2021
Historique:
revised:
16
10
2020
received:
17
04
2020
accepted:
27
10
2020
pubmed:
10
2
2021
medline:
15
5
2021
entrez:
9
2
2021
Statut:
ppublish
Résumé
Trichodysplasia spinulosa (TS) is a rare dermatological disease caused by TS-associated polyomavirus (TSPyV) in immunosuppressed patients. The seroprevalence of TSPyV in immunocompetent adults is high and the number of immunosuppressed patients developing TS remains low, suggesting that TS is underdiagnosed and/or that additional unknown factors are needed in order to develop TS. There is no well-established treatment for TS, and to date a majority of reported cases have consequently received ineffective therapies, likely due to the unavailability of reviews and recommendations of treatments for TS. The few treatments reported in case reports to be effective include topical cidofovir 3%, reduction of immunosuppression and oral valganciclovir. In this comprehensive review, we present all published cases to date, together with a summary of all treatments for TS categorized by overall clinical efficacy, thus addressing this rare disease and what appears to be its clinically efficacious treatment.
Identifiants
pubmed: 33559344
doi: 10.1111/jdv.17081
pmc: PMC8247895
doi:
Substances chimiques
DNA, Viral
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1067-1076Subventions
Organisme : Stiftelsen Clas Groschinskys Minnesfond
ID : M19390
Organisme : Jeanssons Stiftelser
Organisme : Magnus Bergvalls Stiftelse
ID : 2019-03538
Organisme : Cancerfonden
ID : 19 0408 Fk
Organisme : Åke Wiberg Stiftelse
ID : M19-0665
Organisme : Svenska Sällskapet för Medicinsk Forskning
ID : S17-0104
Organisme : Karolinska Institutet
ID : 2018-02203
Organisme : Stockholms Läns Landsting
ID : 20190859
Organisme : Stiftelsen Tornspiran
Organisme : Cancer och Allergifonden
Informations de copyright
© 2020 The Authors. Journal of the European Academy of Dermatology and Venereology published by John Wiley & Sons Ltd on behalf of European Academy of Dermatology and Venereology.
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