Mouse model of Alzheimer's disease demonstrates differential effects of early disease pathology on various brain regions.
APP/PS1
Alzheimer's disease
amyloid beta
cerebellum
cortex
hippocampus
proteomics
Journal
Proteomics
ISSN: 1615-9861
Titre abrégé: Proteomics
Pays: Germany
ID NLM: 101092707
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
revised:
31
01
2021
received:
01
08
2020
accepted:
01
02
2021
pubmed:
10
2
2021
medline:
15
9
2021
entrez:
9
2
2021
Statut:
ppublish
Résumé
Different parts of the brain are affected distinctively in various stages of the Alzheimer's disease (AD) pathogenesis. Identifying the biochemical changes in specific brain regions is key to comprehend the neuropathological mechanisms in early pre-symptomatic phases of AD. Quantitative proteomics profiling of four distinct areas of the brain of young APP/PS1 mouse model of AD was performed followed by biochemical pathway enrichment analysis. Findings revealed fundamental compositional and functional shifts even in the early stages of the disease. This novel study highlights unique proteome and biochemical pathway alterations in specific regions of the brain that underlie the early stages of AD pathology and will provide a framework for future longitudinal studies. The proteomics data were deposited into the ProteomeXchange Consortium via PRIDE with the identifier PXD019192.
Identifiants
pubmed: 33559908
doi: 10.1002/pmic.202000213
doi:
Substances chimiques
Amyloid beta-Protein Precursor
0
Presenilin-1
0
Proteome
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2000213Informations de copyright
© 2021 Wiley-VCH GmbH.
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