Is there an association between labor induction and attention-deficit/hyperactivity disorder among children?
Attention deficit disorder with hyperactivity
Labor induction
Meta-analysis
Journal
Clinical and experimental pediatrics
ISSN: 2713-4148
Titre abrégé: Clin Exp Pediatr
Pays: Korea (South)
ID NLM: 101761234
Informations de publication
Date de publication:
Sep 2021
Sep 2021
Historique:
received:
13
09
2020
accepted:
12
01
2021
pubmed:
10
2
2021
medline:
10
2
2021
entrez:
9
2
2021
Statut:
ppublish
Résumé
There is evidence of destructive effects of oxytocin use during labor on neurodevelopment. This meta-analysis pooled all observational studies to determine the association between labor induction and the risk of attention-deficit/hyperactivity disorder (ADHD) among children. All observational studies (case-control and cohort) were reviewed until September 2020 after searches of the PubMed, Scopus, and Web of Science databases, the gray literature, and conference proceedings. The pooled odds ratios (ORs), relative ratios (RRs), and 95% confidence intervals (CI (swere calculated as random effect estimates of association among studies. All observational studies were reviewed, including 4 cohort studies including 2,885,743 participants and 3 casecontrol studies including 51,135 participants (10,961 with ADHD and 40,174 in control groups) with a sample size of 2,936,878 participants. The pooled estimates of OR and RR did not indicate a significant association between labor induction and ADHD among children (OR, 1.13; 95% CI, 0.90-1.35) and (RR, 1.10; 95% CI, 0.96-1.24). The findings showed that labor induction is not associated with an increased risk of ADHD among children. However, more studies are needed to investigate the relationship between labor induction and ADHD.
Sections du résumé
BACKGROUND
BACKGROUND
There is evidence of destructive effects of oxytocin use during labor on neurodevelopment.
PURPOSE
OBJECTIVE
This meta-analysis pooled all observational studies to determine the association between labor induction and the risk of attention-deficit/hyperactivity disorder (ADHD) among children.
METHODS
METHODS
All observational studies (case-control and cohort) were reviewed until September 2020 after searches of the PubMed, Scopus, and Web of Science databases, the gray literature, and conference proceedings. The pooled odds ratios (ORs), relative ratios (RRs), and 95% confidence intervals (CI (swere calculated as random effect estimates of association among studies.
RESULTS
RESULTS
All observational studies were reviewed, including 4 cohort studies including 2,885,743 participants and 3 casecontrol studies including 51,135 participants (10,961 with ADHD and 40,174 in control groups) with a sample size of 2,936,878 participants. The pooled estimates of OR and RR did not indicate a significant association between labor induction and ADHD among children (OR, 1.13; 95% CI, 0.90-1.35) and (RR, 1.10; 95% CI, 0.96-1.24).
CONCLUSIONS
CONCLUSIONS
The findings showed that labor induction is not associated with an increased risk of ADHD among children. However, more studies are needed to investigate the relationship between labor induction and ADHD.
Identifiants
pubmed: 33561338
pii: cep.2020.01557
doi: 10.3345/cep.2020.01557
pmc: PMC8426101
doi:
Types de publication
Journal Article
Langues
eng
Pagination
489-493Subventions
Organisme : Hamadan University of Medical Sciences
ID : 9907084773
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