Biomarkers for Malignant Pleural Mesothelioma-A Novel View on Inflammation.
immune therapy
infiltrating immune cells
inflammation
malignant pleural mesothelioma
predictive biomarker
prognostic biomarker
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
06 Feb 2021
06 Feb 2021
Historique:
received:
16
12
2020
revised:
25
01
2021
accepted:
02
02
2021
entrez:
10
2
2021
pubmed:
11
2
2021
medline:
11
2
2021
Statut:
epublish
Résumé
Malignant pleural mesothelioma (MPM) is an aggressive disease with limited treatment response and devastating prognosis. Exposure to asbestos and chronic inflammation are acknowledged as main risk factors. Since immune therapy evolved as a promising novel treatment modality, we want to reevaluate and summarize the role of the inflammatory system in MPM. This review focuses on local tumor associated inflammation on the one hand and systemic inflammatory markers, and their impact on MPM outcome, on the other hand. Identification of new biomarkers helps to select optimal patient tailored therapy, avoid ineffective treatment with its related side effects and consequently improves patient's outcome in this rare disease. Additionally, a better understanding of the tumor promoting and tumor suppressing inflammatory processes, influencing MPM pathogenesis and progression, might also reveal possible new targets for MPM treatment. After reviewing the currently available literature and according to our own research, it is concluded that the suppression of the specific immune system and the activation of its innate counterpart are crucial drivers of MPM aggressiveness translating to poor patient outcome.
Identifiants
pubmed: 33562138
pii: cancers13040658
doi: 10.3390/cancers13040658
pmc: PMC7916017
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Références
Br J Cancer. 2003 Jun 2;88(11):1721-6
pubmed: 12771987
J Pathol. 2001 Apr;193(4):468-75
pubmed: 11276005
J Thorac Oncol. 2015 Nov;10(11):1634-41
pubmed: 26317916
Eur J Cardiothorac Surg. 2020 Jul 1;58(1):1-24
pubmed: 32448904
Clin Cancer Res. 2010 Dec 1;16(23):5805-13
pubmed: 20956618
J Thorac Cardiovasc Surg. 2013 May;145(5):1305-11
pubmed: 23072703
Int J Cancer. 2013 May 1;132(9):1977-85
pubmed: 23034889
J Neurosurg Spine. 2018 Nov 1;29(5):549-552
pubmed: 30052149
Hum Pathol. 2018 Jan;71:1-7
pubmed: 28811252
Sci Rep. 2017 Nov 28;7(1):16456
pubmed: 29184132
Oncotarget. 2017 May 9;8(19):32356-32369
pubmed: 28404961
Nature. 2007 Dec 6;450(7171):903-7
pubmed: 18026089
Br J Cancer. 2020 Dec 18;:
pubmed: 33339893
J Thorac Oncol. 2011 Nov;6(11):1923-9
pubmed: 22011651
Ann Surg Oncol. 2018 Jun;25(6):1555-1563
pubmed: 29500763
J Thorac Oncol. 2014 Jul;9(7):1036-1040
pubmed: 24926549
Thorax. 2004 May;59(5):428-33
pubmed: 15115874
Br J Cancer. 2014 Feb 18;110(4):984-90
pubmed: 24434429
J Thorac Oncol. 2016 Oct;11(10):1765-73
pubmed: 27418105
Lung Cancer. 2018 Nov;125:22-28
pubmed: 30429024
PLoS One. 2014 Sep 05;9(9):e106742
pubmed: 25192022
Medicine (Baltimore). 2019 Jul;98(29):e16064
pubmed: 31335668
Lancet. 2016 Apr 2;387(10026):1405-1414
pubmed: 26719230
Cancer Treat Rev. 2015 Dec;41(10):960-70
pubmed: 26604093
Drug Des Devel Ther. 2018 Aug 07;12:2455-2466
pubmed: 30122902
Ann Surg Oncol. 2016 Feb;23(2):646-54
pubmed: 26416715
Sci Rep. 2017 Oct 2;7(1):12557
pubmed: 28970578
Neoplasma. 2017;64(1):114-122
pubmed: 27881012
Am J Pathol. 2011 Sep;179(3):1483-93
pubmed: 21763682
Cell. 2011 Mar 4;144(5):646-74
pubmed: 21376230
Br J Cancer. 2015 Mar 3;112(5):783-92
pubmed: 25633038
Eur J Surg Oncol. 2018 Oct;44(10):1494-1503
pubmed: 30100361
Clin Lung Cancer. 2019 Sep;20(5):e564-e575
pubmed: 31279641
Nat Rev Cancer. 2017 Jul 25;17(8):475-488
pubmed: 28740119
Front Oncol. 2020 Feb 21;10:187
pubmed: 32154179
Immune Netw. 2020 May 20;20(3):e27
pubmed: 32655975
Turk Gogus Kalp Damar Cerrahisi Derg. 2019 Jun 28;27(3):374-380
pubmed: 32082887
Ther Adv Med Oncol. 2020 Nov 12;12:1758835920971421
pubmed: 33240401
J Am Acad Orthop Surg. 2014 Mar;22(3):193-9
pubmed: 24603829
Anticancer Res. 2012 Aug;32(8):3251-8
pubmed: 22843899
Lancet Oncol. 2017 May;18(5):623-630
pubmed: 28291584
Blood. 1989 Aug 15;74(3):940-6
pubmed: 2787682
J Thorac Oncol. 2012 May;7(5):883-9
pubmed: 22729037
PLoS One. 2015 Mar 16;10(3):e0121071
pubmed: 25774992
BMC Cancer. 2019 Nov 29;19(1):1161
pubmed: 31783812
J Clin Oncol. 2005 Jan 1;23(1):184-9
pubmed: 15625372
Clinics (Sao Paulo). 2020 Feb 27;75:e993
pubmed: 32130355
Br J Cancer. 2012 Dec 4;107(12):1978-86
pubmed: 23169291
J Cell Physiol. 2019 Jun;234(6):7983-7993
pubmed: 30317612
World J Surg. 2017 Jun;41(6):1558-1565
pubmed: 28120093
Thorax. 2000 Sep;55(9):731-5
pubmed: 10950889
Dose Response. 2020 Jun 29;18(2):1559325820931290
pubmed: 32647499
Clin Med (Lond). 2009 Feb;9(1):30-3
pubmed: 19271597
Cancer Immunol Res. 2016 Dec;4(12):1038-1048
pubmed: 27856426
Br J Cancer. 2010 Mar 16;102(6):952-6
pubmed: 20160724
Medicine (Baltimore). 2019 Oct;98(40):e17310
pubmed: 31577724
Clin Genitourin Cancer. 2018 Jun;16(3):e685-e693
pubmed: 29454639
Tumour Biol. 2014 Jul;35(7):6839-45
pubmed: 25051913
Oncoimmunology. 2016 Nov 28;6(1):e1261241
pubmed: 28197385
Mod Pathol. 2020 Aug;33(8):1458-1465
pubmed: 32291396
Ther Adv Med Oncol. 2020 Sep 29;12:1758835920962362
pubmed: 33062064
Eur J Cardiothorac Surg. 2010 Sep;38(3):245-52
pubmed: 20338775
Lung Cancer. 2017 Sep;111:176-181
pubmed: 28838390
Int J Mol Sci. 2018 Mar 30;19(4):
pubmed: 29601534
N Engl J Med. 1999 Feb 11;340(6):448-54
pubmed: 9971870
Front Immunol. 2017 Nov 20;8:1559
pubmed: 29209316
Sci Rep. 2016 Mar 04;6:22618
pubmed: 26939789
J Thorac Oncol. 2012 Apr;7(4):755-9
pubmed: 22425926
J Pathol. 2012 Nov;228(3):366-77
pubmed: 22864872
Medicine (Baltimore). 2019 Sep;98(37):e16974
pubmed: 31517816
Chest. 1998 Mar;113(3):723-31
pubmed: 9515850
Br J Cancer. 1998 Mar;77(6):907-12
pubmed: 9528833
J Thorac Dis. 2016 Aug;8(8):2121-7
pubmed: 27621868
Eur Respir J. 2006 Jun;27(6):1086-95
pubmed: 16540497
Ann Surg. 2012 Aug;256(2):357-62
pubmed: 22750759
J Thorac Cardiovasc Surg. 2008 Apr;135(4):823-9
pubmed: 18374762
Lung Cancer. 2015 Jun;88(3):332-7
pubmed: 25843042
Interact Cardiovasc Thorac Surg. 2015 Dec;21(6):777-86
pubmed: 26362629
Am J Clin Oncol. 2018 Dec;41(12):1193-1198
pubmed: 29782360
Cancers (Basel). 2020 Dec 05;12(12):
pubmed: 33291370
In Vivo. 2018 Mar-Apr;32(2):445-450
pubmed: 29475935
J Thorac Dis. 2018 Jan;10(Suppl 2):S285-S292
pubmed: 29507797
J Gastroenterol Hepatol. 2019 Feb;34(2):355-363
pubmed: 30119141
Mol Cancer. 2013 Apr 05;12:26
pubmed: 23561329
J Cell Physiol. 2019 Jun;234(6):8509-8521
pubmed: 30520029
Adv Anat Pathol. 2017 Nov;24(6):311-335
pubmed: 28777143
Free Radic Biol Med. 2019 Mar;133:206-215
pubmed: 30312759
Medicine (Baltimore). 2018 Dec;97(50):e13505
pubmed: 30558004
Cells. 2020 Dec 03;9(12):
pubmed: 33287315
Eur J Intern Med. 2016 Nov;35:e16-e17
pubmed: 27491588
Thorax. 2013 Jul;68(7):670-6
pubmed: 22744884
J Clin Oncol. 1989 Aug;7(8):1157-68
pubmed: 2666592
Oncotarget. 2017 May 9;8(19):32171-32189
pubmed: 28418870
Oncol Res Treat. 2019;42(6):334-341
pubmed: 31063993
Eur J Cancer. 2005 Jul;41(11):1645-8
pubmed: 15964184
BMC Cancer. 2019 Dec 10;19(1):1204
pubmed: 31823764
J Clin Oncol. 2003 Jul 15;21(14):2636-44
pubmed: 12860938
Environ Health Prev Med. 2016 Sep;21(5):304-311
pubmed: 27068290
Support Care Cancer. 2013 Mar;21(3):697-705
pubmed: 22936495
Oncotarget. 2018 Apr 24;9(31):21861-21875
pubmed: 29774108
Cancer. 2011 Nov 15;117(22):5234-44
pubmed: 21523763
Interact Cardiovasc Thorac Surg. 2015 Nov;21(5):616-23
pubmed: 26242317
J Thorac Oncol. 2019 Feb;14(2):288-293
pubmed: 30366103
Int J Cancer. 2006 Sep 15;119(6):1303-11
pubmed: 16642474
Mol Cancer Ther. 2013 Jun;12(6):844-52
pubmed: 23729401
Ann Oncol. 2018 May 1;29(5):1258-1265
pubmed: 29514216
Front Oncol. 2019 Dec 06;9:1366
pubmed: 31867277
Nat Rev Clin Oncol. 2011 Aug 23;8(10):587-96
pubmed: 21862978
J Clin Med. 2020 Jul 08;9(7):
pubmed: 32650433
Eur Respir J. 2020 Jun 11;55(6):
pubmed: 32451346
BMC Cancer. 2017 Apr 21;17(1):285
pubmed: 28431566
Thorac Surg Clin. 2020 Nov;30(4):435-449
pubmed: 33012431
Oncotarget. 2017 Jul 18;8(29):47090-47102
pubmed: 28514756
Med Oncol. 2013 Mar;30(1):333
pubmed: 23269580
Am J Respir Crit Care Med. 2014 Oct 1;190(7):763-72
pubmed: 25188816
Urol Oncol. 2017 Sep;35(9):544.e25-544.e31
pubmed: 28572026
Ann Cardiothorac Surg. 2012 Nov;1(4):516-22
pubmed: 23977546
Onco Targets Ther. 2018 Apr 05;11:1899-1908
pubmed: 29670365
J Thorac Oncol. 2012 Mar;7(3):587-94
pubmed: 22307011
PLoS One. 2013;8(3):e59321
pubmed: 23555017
Clin Cancer Res. 2002 Jun;8(6):1857-62
pubmed: 12060628
J Cancer. 2020 Jan 20;11(7):1816-1827
pubmed: 32194793
Carcinogenesis. 2018 Apr 5;39(4):534-545
pubmed: 29635378
J Clin Oncol. 1998 Jan;16(1):145-52
pubmed: 9440736
Br J Cancer. 2021 Feb;124(3):564-566
pubmed: 33100328
BMC Cancer. 2010 Aug 30;10:464
pubmed: 20804550
Cancer Treat Res Commun. 2019;19:100127
pubmed: 30913495
Jpn J Clin Oncol. 2011 Jan;41(1):32-9
pubmed: 20798232
Nutr Clin Pract. 2019 Jun;34(3):340-348
pubmed: 30908744
Nature. 2008 Jul 24;454(7203):436-44
pubmed: 18650914
Carcinogenesis. 2013 Jul;34(7):1413-9
pubmed: 23677068
Asian J Androl. 2014 May-Jun;16(3):467-71
pubmed: 24589465
Nat Immunol. 2015 May;16(5):448-57
pubmed: 25898198
Lung Cancer. 2014 Oct;86(1):29-34
pubmed: 25175318
J Clin Invest. 2003 Jun;111(12):1805-12
pubmed: 12813013
Cancers (Basel). 2020 Aug 17;12(8):
pubmed: 32824422
Cancer Immunol Immunother. 2010 Oct;59(10):1543-9
pubmed: 20567822
Nature. 2002 Dec 19-26;420(6917):860-7
pubmed: 12490959
PLoS One. 2018 Feb 15;13(2):e0193018
pubmed: 29447258
S Afr Med J. 1982 Jun 26;61(26):1007-9
pubmed: 7089768
Growth Factors. 1994;11(1):29-44
pubmed: 7833058
Ther Adv Med Oncol. 2019 Aug 28;11:1758835919870360
pubmed: 31497071
Am J Cardiol. 2003 Jul 3;92(1A):10i-8i
pubmed: 12867250
J Thorac Oncol. 2018 Oct;13(10):1569-1576
pubmed: 29908324
Transl Lung Cancer Res. 2015 Feb;4(1):55-66
pubmed: 25806346
Sci Rep. 2020 Apr 1;10(1):5784
pubmed: 32238865
Asian Pac J Cancer Prev. 2013;14(10):5735-40
pubmed: 24289571
Rev Cardiovasc Med. 2019 Sep 30;20(3):161-169
pubmed: 31601090
J Cell Physiol. 2019 May;234(5):5683-5699
pubmed: 30341914
J Thorac Oncol. 2016 Feb;11(2):249-55
pubmed: 26845118
Oncoimmunology. 2017 Jan 6;6(2):e1278330
pubmed: 28344893
Ann Oncol. 2013 May;24(5):1170-9
pubmed: 23393121
Int J Cancer. 1992 May 8;51(2):296-301
pubmed: 1373705
Br J Cancer. 2001 Sep 14;85(6):863-8
pubmed: 11556838
Clin Chim Acta. 2018 Aug;483:48-56
pubmed: 29678631
ScientificWorldJournal. 2014 Jan 23;2014:902748
pubmed: 24592197
Br J Ind Med. 1960 Oct;17:260-71
pubmed: 13782506
Nutr J. 2010 Dec 22;9:69
pubmed: 21176210
Ann Oncol. 2016 Aug;27(8):1386-422
pubmed: 27380959
J Exp Med. 1930 Sep 30;52(4):561-71
pubmed: 19869788
JAMA Oncol. 2019 Mar 1;5(3):351-357
pubmed: 30605211
Breast Cancer Res. 2017 Jan 5;19(1):2
pubmed: 28057046
Oncotarget. 2016 May 31;7(22):31926-42
pubmed: 26942464
Br J Cancer. 2013 Oct 1;109(7):1813-20
pubmed: 23982605
Br J Cancer. 1995 Feb;71(2):354-6
pubmed: 7841052
Cancer Treat Rev. 2013 Aug;39(5):534-40
pubmed: 22995477
Lung Cancer. 2012 Feb;75(2):248-54
pubmed: 21757252
Cancer Res. 1994 Aug 15;54(16):4419-23
pubmed: 8044791
J Thorac Oncol. 2016 Apr;11(4):573-82
pubmed: 26776867
Eur J Cancer. 2016 Aug;63:64-73
pubmed: 27288871
J Surg Oncol. 2017 Mar;115(4):470-479
pubmed: 28105646
Cancer Sci. 2018 Feb;109(2):330-339
pubmed: 29193587
Cancer Res. 2000 Jul 15;60(14):3696-700
pubmed: 10919635
Oncoimmunology. 2015 Mar 19;4(6):e1009285
pubmed: 26155428
Cell Immunol. 2019 Sep;343:103753
pubmed: 29395859
Oncology (Williston Park). 2020 Nov 12;34(11):502-503
pubmed: 33206991
J Thorac Oncol. 2010 Jul;5(7):988-92
pubmed: 20453690
J Immunother Cancer. 2020 Jun;8(1):
pubmed: 32581053
J Cancer Res Clin Oncol. 2021 Feb;147(2):459-468
pubmed: 33216211
J Natl Compr Canc Netw. 2019 Dec;17(12):1464-1472
pubmed: 31805526
Front Oncol. 2020 Feb 18;10:126
pubmed: 32133285
Lancet. 2005 Jul 30-Aug 5;366(9483):397-408
pubmed: 16054941
J Biol Chem. 2004 Nov 19;279(47):48487-90
pubmed: 15337754
Int Immunol. 2017 Nov 1;29(9):401-409
pubmed: 28541437
Am J Pathol. 2011 Mar;178(3):1033-42
pubmed: 21356356
Oncotarget. 2017 Dec 22;9(4):5058-5072
pubmed: 29435162
Curr Drug Targets. 2019;20(3):302-315
pubmed: 30073924
Cancers (Basel). 2020 Feb 05;12(2):
pubmed: 32033266
Anticancer Res. 2010 Jun;30(6):1947-52
pubmed: 20651338
Cells. 2019 Sep 16;8(9):
pubmed: 31527449
Oncotarget. 2018 Jul 3;9(51):29820-29841
pubmed: 30038723
Int J Cancer. 2004 Apr 10;109(3):322-8
pubmed: 14961568
Expert Rev Respir Med. 2015 Oct;9(5):633-54
pubmed: 26308799