Medulloblastoma Associated with Down Syndrome: From a Rare Event Leading to a Pathogenic Hypothesis.
Down syndrome
brain tumor
cancer predisposition syndrome
medulloblastoma
Journal
Diagnostics (Basel, Switzerland)
ISSN: 2075-4418
Titre abrégé: Diagnostics (Basel)
Pays: Switzerland
ID NLM: 101658402
Informations de publication
Date de publication:
07 Feb 2021
07 Feb 2021
Historique:
received:
08
01
2021
revised:
29
01
2021
accepted:
01
02
2021
entrez:
10
2
2021
pubmed:
11
2
2021
medline:
11
2
2021
Statut:
epublish
Résumé
Down syndrome (DS) is the most common chromosome abnormality with a unique cancer predisposition syndrome pattern: a higher risk to develop acute leukemia and a lower incidence of solid tumors. In particular, brain tumors are rarely reported in the DS population, and biological behavior and natural history are not well described and identified. We report a case of a 10-year-old child with DS who presented with a medulloblastoma (MB). Histological examination revealed a classic MB with focal anaplasia and the molecular profile showed the presence of a
Identifiants
pubmed: 33562188
pii: diagnostics11020254
doi: 10.3390/diagnostics11020254
pmc: PMC7915142
pii:
doi:
Types de publication
Case Reports
Langues
eng
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