Circulating Adiponectin and Its Association with Metabolic Traits and Type 2 Diabetes: Gene-Diet Interactions Focusing on Selected Gene Variants and at the Genome-Wide Level in High-Cardiovascular Risk Mediterranean Subjects.
Adiponectin
/ blood
Aged
Aged, 80 and over
Cardiovascular Diseases
/ etiology
Diabetes Mellitus, Type 2
/ genetics
Diet, Mediterranean
Female
Genome-Wide Association Study
Humans
Male
Metabolic Syndrome
/ genetics
Middle Aged
Polymorphism, Single Nucleotide
Risk
Vesicular Transport Proteins
/ genetics
Mediterranean diet
adiponectin
body mass index
genetics
gene–diet interactions
genome-wide association study
plasma lipids
polymorphisms
type 2 diabetes
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
07 Feb 2021
07 Feb 2021
Historique:
received:
20
12
2020
revised:
26
01
2021
accepted:
02
02
2021
entrez:
10
2
2021
pubmed:
11
2
2021
medline:
8
9
2021
Statut:
epublish
Résumé
Adiponectin is gaining renewed interest since, in addition to its possible protective role against insulin resistance and arteriosclerosis, recent studies suggest other additional favorable effects. However, the influence of gene-diet interactions on plasma adiponectin levels is still little understood. We analyzed the association between plasma adiponectin levels and various metabolic traits in a high-cardiovascular risk Mediterranean population, as well as the genetic effect of four candidate single-nucleotide polymorphisms (SNPs) in the adiponectin gene (
Identifiants
pubmed: 33562295
pii: nu13020541
doi: 10.3390/nu13020541
pmc: PMC7914877
pii:
doi:
Substances chimiques
Adiponectin
0
VAT1 protein, human
0
Vesicular Transport Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Generalitat Valenciana
ID : PROMETEO 17/2017
Organisme : Fundació La Marató de TV3
ID : 538/U/2016
Organisme : Spanish Ministry of Health (Instituto de Salud Carlos III) and the Ministerio de Economía y Competitividad-Fondo Europeo de Desarrollo Regional (FEDER)
ID : CIBER 06/03
Organisme : Spanish Ministry of Health (Instituto de Salud Carlos III) and the Ministerio de Economía y Competitividad-Fondo Europeo de Desarrollo Regional (FEDER)
ID : PI06/1326
Organisme : Spanish Ministry of Health (Instituto de Salud Carlos III) and the Ministerio de Economía y Competitividad-Fondo Europeo de Desarrollo Regional (FEDER)
ID : PI13/00728
Organisme : Spanish Ministry of Health (Instituto de Salud Carlos III) and the Ministerio de Economía y Competitividad-Fondo Europeo de Desarrollo Regional (FEDER)
ID : PI16/00366
Organisme : Spanish Ministry of Health (Instituto de Salud Carlos III) and the Ministerio de Economía y Competitividad-Fondo Europeo de Desarrollo Regional (FEDER)
ID : PI19/00781
Organisme : Spanish Ministry of Health (Instituto de Salud Carlos III) and the Ministerio de Economía y Competitividad-Fondo Europeo de Desarrollo Regional (FEDER)
ID : SAF2016-80532-R
Organisme : University Jaume I
ID : P1-1B2013-54 and COGRUP/2016/06
Organisme : The Rei Jaume I Award for Medical Research 2018
ID : Medical Research 2018
Organisme : Generalitat Valenciana
ID : APOSTD/2019/136
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