Emerging Roles for Ion Channels in Ovarian Cancer: Pathomechanisms and Pharmacological Treatment.
chemoresistance
drug resistance
ion channels
ovarian cancer
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
07 Feb 2021
07 Feb 2021
Historique:
received:
05
11
2020
revised:
21
01
2021
accepted:
04
02
2021
entrez:
10
2
2021
pubmed:
11
2
2021
medline:
11
2
2021
Statut:
epublish
Résumé
Ovarian cancer (OC) is the deadliest gynecologic cancer, due to late diagnosis, development of platinum resistance, and inadequate alternative therapy. It has been demonstrated that membrane ion channels play important roles in cancer processes, including cell proliferation, apoptosis, motility, and invasion. Here, we review the contribution of ion channels in the development and progression of OC, evaluating their potential in clinical management. Increased expression of voltage-gated and epithelial sodium channels has been detected in OC cells and tissues and shown to be involved in cancer proliferation and invasion. Potassium and calcium channels have been found to play a critical role in the control of cell cycle and in the resistance to apoptosis, promoting tumor growth and recurrence. Overexpression of chloride and transient receptor potential channels was found both in vitro and in vivo, supporting their contribution to OC. Furthermore, ion channels have been shown to influence the sensitivity of OC cells to neoplastic drugs, suggesting a critical role in chemotherapy resistance. The study of ion channels expression and function in OC can improve our understanding of pathophysiology and pave the way for identifying ion channels as potential targets for tumor diagnosis and treatment.
Identifiants
pubmed: 33562306
pii: cancers13040668
doi: 10.3390/cancers13040668
pmc: PMC7914442
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Ministero dell'Istruzione, dell'Università e della Ricerca
ID : PRIN n. 20174TB8KW_002
Références
Mol Cancer Ther. 2016 Mar;15(3):460-70
pubmed: 26832797
Sci Rep. 2018 Oct 3;8(1):14725
pubmed: 30282979
Autophagy. 2012 Apr;8(4):707-8
pubmed: 22498475
Oncol Lett. 2019 Jun;17(6):5653-5661
pubmed: 31186788
Curr Cancer Drug Targets. 2013 Jan;13(1):103-16
pubmed: 22920441
Cancer Cell. 2009 Feb 3;15(2):124-34
pubmed: 19185847
Oncologist. 2017 Apr;22(4):450-459
pubmed: 28314837
Front Microbiol. 2012 Aug 08;3:286
pubmed: 23024638
Oncol Rep. 2015 May;33(5):2227-34
pubmed: 25738998
J Cancer Res Clin Oncol. 2004 Jul;130(7):423-8
pubmed: 15156398
Carcinogenesis. 2016 Mar;37(3):290-300
pubmed: 26775040
Oncogene. 2009 Mar 12;28(10):1320-8
pubmed: 19151765
Nature. 2009 Feb 12;457(7231):901-5
pubmed: 19118385
Cancer Invest. 2011 Jun;29(5):339-46
pubmed: 21438841
Br J Cancer. 2014 Mar 4;110(5):1392-401
pubmed: 24473401
J Biol Chem. 1997 May 9;272(19):12575-82
pubmed: 9139710
Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15225-30
pubmed: 21876174
J Natl Cancer Inst. 2019 Feb 1;111(2):137-145
pubmed: 29860330
Oncogene. 2007 Apr 12;26(17):2525-34
pubmed: 17146446
J Cardiovasc Pharmacol. 1996 Mar;27(3):401-10
pubmed: 8907802
Pflugers Arch. 2020 Jul;472(7):961-975
pubmed: 32361781
Front Pharmacol. 2015 Nov 12;6:273
pubmed: 26834632
Biochem Pharmacol. 2020 Jan;171:113695
pubmed: 31706846
Clin Transl Oncol. 2013 Nov;15(11):910-8
pubmed: 23479219
Trends Mol Med. 2010 Mar;16(3):107-21
pubmed: 20167536
Int Immunopharmacol. 2017 Apr;45:74-78
pubmed: 28189971
Oncotarget. 2015 Oct 20;6(32):32914-29
pubmed: 26452220
FEBS Lett. 2014 Aug 25;588(17):2971-7
pubmed: 24911199
Eur J Gynaecol Oncol. 2008;29(3):267-71
pubmed: 18592793
Oncotarget. 2017 Aug 18;8(42):72324-72341
pubmed: 29069790
BMC Cancer. 2016 Nov 4;16(1):846
pubmed: 27809800
Oncotarget. 2016 Jun 14;7(24):36168-36184
pubmed: 27102434
J Clin Hypertens (Greenwich). 2019 Feb;21(2):252-261
pubmed: 30582271
J Membr Biol. 1996 Nov;154(2):91-107
pubmed: 8929284
J Biol Chem. 2009 Mar 27;284(13):8680-91
pubmed: 19176528
Mol Med Rep. 2018 Aug;18(2):1377-1386
pubmed: 29901154
Nutrients. 2019 Oct 05;11(10):
pubmed: 31590362
Antimicrob Agents Chemother. 2014 Sep;58(9):5068-78
pubmed: 24913175
Biosci Trends. 2014 Feb;8(1):1-10
pubmed: 24647107
Drug Des Devel Ther. 2019 Aug 09;13:2777-2786
pubmed: 31496654
Channels (Austin). 2017 Sep 3;11(5):373-376
pubmed: 28650687
Cephalalgia. 2007 May;27(5):422-8
pubmed: 17448180
Obstet Gynecol Clin North Am. 2007 Dec;34(4):651-65, vii-viii
pubmed: 18061862
Lab Invest. 2002 Dec;82(12):1755-64
pubmed: 12480925
Int J Cancer. 2019 May 1;144(9):2215-2226
pubmed: 30243029
Cell Calcium. 2020 Nov;91:102258
pubmed: 32736154
Am J Pathol. 2011 Jul;179(1):400-10
pubmed: 21703419
Diagn Pathol. 2010 Dec 07;5:78
pubmed: 21138547
Oncotarget. 2016 Sep 20;7(38):61403-61418
pubmed: 27528021
Cancer Chemother Pharmacol. 1994;35(2):137-43
pubmed: 7987990
J Biol Chem. 2009 Feb 6;284(6):3855-64
pubmed: 18996841
Int J Mol Sci. 2020 Mar 27;21(7):
pubmed: 32230901
Drug Metab Dispos. 2011 Jul;39(7):1188-95
pubmed: 21447734
Nat Rev Cancer. 2005 Apr;5(4):275-84
pubmed: 15803154
Antibodies (Basel). 2019 May 24;8(2):
pubmed: 31544839
Physiology (Bethesda). 2004 Oct;19:285-92
pubmed: 15381757
BMC Cancer. 2015 Mar 11;15:117
pubmed: 25886033
J Neurosci. 2002 Mar 1;22(5):1840-9
pubmed: 11880513
Anesthesiology. 2006 Oct;105(4):660-4
pubmed: 17006061
Cancer Cell. 2003 Mar;3(3):297-302
pubmed: 12676587
Front Physiol. 2020 Aug 21;11:978
pubmed: 32973546
Pflugers Arch. 2010 Mar;459(4):579-92
pubmed: 19888597
J Proteomics. 2013 Aug 26;89:165-78
pubmed: 23792823
Biochim Biophys Acta Mol Basis Dis. 2017 Jan;1863(1):81-91
pubmed: 27773735
Front Cell Dev Biol. 2020 Dec 14;8:611853
pubmed: 33381507
Oncotarget. 2016 Jun 14;7(24):36419-36435
pubmed: 27183905
Cancers (Basel). 2020 Aug 10;12(8):
pubmed: 32785177
Oncotarget. 2015 May 10;6(13):11585-99
pubmed: 25839162
Semin Oncol Nurs. 2019 Apr;35(2):151-156
pubmed: 30867104
Biochem Biophys Res Commun. 2014 Nov 28;454(4):547-53
pubmed: 25450691
Exp Ther Med. 2018 Jun;15(6):4943-4949
pubmed: 29805518
J Anesth Clin Res. 2017 Jan;8(1):
pubmed: 28239510
Semin Cancer Biol. 2017 Jun;44:67-71
pubmed: 28450177
J Dermatol Sci. 2011 Jan;61(1):7-13
pubmed: 21167690
Sci Rep. 2016 May 19;6:26277
pubmed: 27195613
Cancers (Basel). 2019 Oct 28;11(11):
pubmed: 31661908
Clin Cancer Res. 1995 Oct;1(10):1223-32
pubmed: 9815916
JPEN J Parenter Enteral Nutr. 2015 Sep;39(1 Suppl):18S-32S
pubmed: 26177664
Cell Calcium. 2019 Jul;81:38-50
pubmed: 31200184
Cell Calcium. 2010 Dec;48(6):315-23
pubmed: 21075448
Biochim Biophys Acta. 2015 Oct;1848(10 Pt B):2493-501
pubmed: 25922224
Int J Mol Med. 2012 Sep;30(3):487-94
pubmed: 22692672
Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):E1667-E1674
pubmed: 29382763
PLoS One. 2012;7(8):e41664
pubmed: 22899999
Proc Natl Acad Sci U S A. 2013 Mar 12;110(11):E1026-34
pubmed: 23431153
Gynecol Oncol. 2005 Oct;99(1):58-64
pubmed: 16043214
Cancer. 2007 Jan 15;109(2):221-7
pubmed: 17154394
J Clin Exp Oncol. 2012 Nov 1;1(2):
pubmed: 24163825
Cell Calcium. 2019 Jul;81:59-66
pubmed: 31203007
Molecules. 2019 Aug 13;24(16):
pubmed: 31412624
Am J Pathol. 1994 May;144(5):906-14
pubmed: 7513949
Curr Med Chem. 2009;16(1):66-93
pubmed: 19149563
Biochim Biophys Acta. 2015 Oct;1848(10 Pt B):2603-20
pubmed: 25450343
Front Cell Neurosci. 2015 Mar 17;9:86
pubmed: 25852478
Anticancer Res. 2013 Apr;33(4):1401-8
pubmed: 23564779
Cell Mol Life Sci. 2015 Oct;72(19):3677-93
pubmed: 26070303
Oncotarget. 2016 Dec 13;7(50):83187-83199
pubmed: 27825122
Nat Rev Cancer. 2009 Jun;9(6):415-28
pubmed: 19461667
Cancer Res. 2007 Aug 1;67(15):7343-9
pubmed: 17671204
PLoS One. 2015 Aug 25;10(8):e0136584
pubmed: 26305547
Biochem Biophys Res Commun. 2008 Oct 17;375(2):205-9
pubmed: 18706395
Cancer Genomics Proteomics. 2020 May-Jun;17(3):309-319
pubmed: 32345672
Br J Pharmacol. 2019 Oct;176(19):3845-3856
pubmed: 31271653
Cell Calcium. 2014 Jul;56(1):14-24
pubmed: 24813114
Nat Commun. 2017 Feb 15;8:14206
pubmed: 28198360
Eur J Gynaecol Oncol. 2016;37(5):689-695
pubmed: 29787012
Int J Oncol. 2016 Jan;48(1):243-52
pubmed: 26647723
Int J Oncol. 2018 Aug;53(2):855-865
pubmed: 29901108
Br J Cancer. 2018 Jan;118(2):200-212
pubmed: 29161243
Pharmacology. 2005 Mar;73(3):162-8
pubmed: 15637453
Cell Death Dis. 2015 Feb 26;6:e1658
pubmed: 25719243
Mol Membr Biol. 2003 Jan-Mar;20(1):1-11
pubmed: 12745921
Front Pharmacol. 2020 Oct 16;11:568993
pubmed: 33178018
Gynecol Oncol. 2014 Jan;132(1):211-20
pubmed: 24262875
BJU Int. 2011 Jul;108(2):276-9
pubmed: 21083640
Cancer Biother Radiopharm. 2019 Dec;34(10):642-649
pubmed: 31549859
J Transl Med. 2013 Nov 06;11:282
pubmed: 24195657
J Trace Elem Med Biol. 2017 Dec;44:88-92
pubmed: 28965607
Cancer Cell Int. 2011 Mar 10;11:6
pubmed: 21392380
Cancer. 2009 Mar 15;115(6):1234-44
pubmed: 19189349
Mol Cancer. 2014 Dec 11;13:262
pubmed: 25495823
Front Pharmacol. 2019 Jun 05;10:606
pubmed: 31231216
Phytochemistry. 2016 May;125:5-13
pubmed: 26899361
Cell Calcium. 2019 Sep;82:102050
pubmed: 31279157
Invest New Drugs. 2017 Jun;35(3):324-333
pubmed: 28150073
Cancer Res. 2010 Feb 1;70(3):1173-83
pubmed: 20103623
CA Cancer J Clin. 2019 Jul;69(4):280-304
pubmed: 31099893
J Cell Physiol. 2018 May;233(5):3755-3768
pubmed: 28776687
Front Pharmacol. 2016 May 10;7:121
pubmed: 27242528
J Physiol. 2018 Jan 15;596(2):217-229
pubmed: 29134661
Oncol Rep. 2010 May;23(5):1293-9
pubmed: 20372843
Biochim Biophys Acta. 2015 Oct;1848(10 Pt B):2638-46
pubmed: 25445667
Ann Pharmacother. 2013 Apr;47(4):578-85
pubmed: 23548650
Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7803-7
pubmed: 12782791
Oncogene. 2007 Nov 15;26(52):7380-5
pubmed: 17533368
Nat Rev Drug Discov. 2009 Feb;8(2):153-71
pubmed: 19153558
Tumour Biol. 2016 Feb;37(2):2565-73
pubmed: 26386726
Nat Rev Mol Cell Biol. 2003 Jul;4(7):517-29
pubmed: 12838335
Transl Oncol. 2018 Apr;11(2):292-299
pubmed: 29413762
Apoptosis. 2007 Oct;12(10):1837-46
pubmed: 17624594
J Cancer. 2018 Aug 6;9(17):3196-3207
pubmed: 30210643
Sci Rep. 2016 Jul 25;6:30276
pubmed: 27451945
Gynecol Oncol. 2007 Feb;104(2):455-60
pubmed: 17014896
Biochim Biophys Acta. 2015 Oct;1848(10 Pt B):2685-702
pubmed: 25542783
Physiol Rev. 2018 Apr 1;98(2):559-621
pubmed: 29412049
Cell. 1995 Jan 27;80(2):259-68
pubmed: 7834745
Int J Cancer. 2001 Sep;93(6):911-5
pubmed: 11519057
Sci Transl Med. 2017 Jun 14;9(394):
pubmed: 28615356
Onco Targets Ther. 2016 Jan 14;9:325-33
pubmed: 26834491
Obstet Gynecol. 1990 Feb;75(2):263-73
pubmed: 2300355
J Cell Physiol. 2012 Jun;227(6):2542-55
pubmed: 21898399
Clin Cancer Res. 2013 Mar 1;19(5):961-8
pubmed: 23307860
Breast Cancer Res Treat. 2012 Jul;134(2):603-15
pubmed: 22678159
Int J Oncol. 2013 Apr;42(4):1305-16
pubmed: 23404140
Cancer Lett. 2012 Dec 29;326(1):41-51
pubmed: 22820160
Bioorg Med Chem Lett. 2013 Dec 15;23(24):6656-62
pubmed: 24220170
Cold Spring Harb Perspect Biol. 2011 Dec 01;3(12):
pubmed: 21791698
Int J Gynecol Cancer. 2009 May;19(4):526-30
pubmed: 19509546
J Proteome Res. 2012 Feb 3;11(2):678-91
pubmed: 22032327
Oncotarget. 2014 Jul 15;5(13):4799-810
pubmed: 25015419
Compr Physiol. 2018 Sep 14;8(4):1463-1511
pubmed: 30215858
J Cell Sci. 2013 Nov 1;126(Pt 21):4835-42
pubmed: 23902689
Philos Trans R Soc Lond B Biol Sci. 2014 Feb 03;369(1638):20130108
pubmed: 24493756
Basic Clin Pharmacol Toxicol. 2004 May;94(5):245-51
pubmed: 15125695
BMB Rep. 2020 Mar;53(3):125-132
pubmed: 32172727
Sleep. 2005 Oct;28(10):1271-8
pubmed: 16295212
J Cell Sci. 2016 Nov 15;129(22):4165-4174
pubmed: 27852828
Cancers (Basel). 2019 Aug 09;11(8):
pubmed: 31395807
Inflammopharmacology. 2016 Dec;24(6):319-334
pubmed: 27757590
J Biol Chem. 2015 Jul 10;290(28):17218-27
pubmed: 26004777
J Ovarian Res. 2020 Feb 22;13(1):20
pubmed: 32087757
Mol Med Rep. 2016 Jan;13(1):265-72
pubmed: 26549617
Biochim Biophys Acta. 2015 Oct;1848(10 Pt B):2523-31
pubmed: 25546839
Biochim Biophys Acta Rev Cancer. 2020 Apr;1873(2):188355
pubmed: 32135169
CA Cancer J Clin. 2018 Nov;68(6):394-424
pubmed: 30207593
Philos Trans R Soc Lond B Biol Sci. 2014 Feb 03;369(1638):20130092
pubmed: 24493741
Front Pharmacol. 2020 May 08;11:577
pubmed: 32457608
Am J Physiol Cell Physiol. 2010 Dec;299(6):C1493-503
pubmed: 20861471
Mol Cancer. 2010 Aug 04;9:207
pubmed: 20684763
Sci Rep. 2017 Jun 28;7(1):4340
pubmed: 28659615
EMBO J. 2001 Sep 3;20(17):4634-8
pubmed: 11532927
Biochem Biophys Res Commun. 2019 May 7;512(3):467-472
pubmed: 30902388
Cancer Med. 2021 Jan;10(1):337-349
pubmed: 33280262
Cephalalgia. 2020 Mar;40(3):321-322
pubmed: 31955597
Am J Transl Res. 2018 Jun 15;10(6):1663-1676
pubmed: 30018708
Cell Death Dis. 2019 Feb 22;10(3):186
pubmed: 30796197
Cancer Res. 2010 Sep 1;70(17):6957-67
pubmed: 20651255
Endocr Relat Cancer. 2010 Mar 08;17(2):335-49
pubmed: 20215102
Cochrane Database Syst Rev. 2014 May 19;(5):CD010769
pubmed: 24838845
Eur J Cancer. 2013 Jul;49(10):2331-44
pubmed: 23683551
Cell Physiol Biochem. 2017;44(2):763-777
pubmed: 29169174
J Physiol. 2017 May 15;595(10):3063-3075
pubmed: 28304082
Oncotarget. 2015 Apr 20;6(11):9173-88
pubmed: 25823819
Gen Physiol Biophys. 2012 Jun;31(2):119-30
pubmed: 22781815
Sci Rep. 2019 Nov 28;9(1):17784
pubmed: 31780732
Oncol Rep. 2014 Feb;31(2):940-6
pubmed: 24337203
Am J Physiol Cell Physiol. 2011 Sep;301(3):C541-9
pubmed: 21543740
Anticancer Res. 2019 Apr;39(4):1661-1666
pubmed: 30952704
Nat Biotechnol. 2005 Oct;23(10):1289-93
pubmed: 16170312
Reprod Sci. 2015 Dec;22(12):1618-26
pubmed: 26079730
Int J Cancer. 2001 Aug 15;93(4):577-83
pubmed: 11477563
Mol Membr Biol. 2004 Jan-Feb;21(1):27-38
pubmed: 14668136
J Biol Chem. 2015 Jun 26;290(26):16116-31
pubmed: 25971967
Cell Calcium. 2005 Sep-Oct;38(3-4):233-52
pubmed: 16098585