Exercise Training Promotes Sex-Specific Adaptations in Mouse Inguinal White Adipose Tissue.
Adaptation, Physiological
/ physiology
Adipose Tissue, Beige
/ physiology
Adipose Tissue, White
/ physiology
Animals
Cell Transdifferentiation
Cells, Cultured
Female
Inguinal Canal
Male
Mice
Mice, Inbred C57BL
Physical Conditioning, Animal
/ physiology
Sex Characteristics
Subcutaneous Fat, Abdominal
/ physiology
Journal
Diabetes
ISSN: 1939-327X
Titre abrégé: Diabetes
Pays: United States
ID NLM: 0372763
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
received:
30
07
2020
accepted:
01
02
2021
pubmed:
11
2
2021
medline:
3
9
2021
entrez:
10
2
2021
Statut:
ppublish
Résumé
Recent studies demonstrate that adaptations to white adipose tissue (WAT) are important components of the beneficial effects of exercise training on metabolic health. Exercise training favorably alters the phenotype of subcutaneous inguinal WAT (iWAT) in male mice, including decreasing fat mass, improving mitochondrial function, inducing beiging, and stimulating the secretion of adipokines. In this study, we find that despite performing more voluntary wheel running compared with males, these adaptations do not occur in the iWAT of female mice. Consistent with sex-specific adaptations, we report that mRNA expression of androgen receptor coactivators is upregulated in iWAT from trained male mice and that testosterone treatment of primary adipocytes derived from the iWAT of male, but not female mice, phenocopies exercise-induced metabolic adaptations. Sex specificity also occurs in the secretome profile, as we identify cysteine-rich secretory protein 1 (
Identifiants
pubmed: 33563587
pii: db20-0790
doi: 10.2337/db20-0790
pmc: PMC8275891
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1250-1264Subventions
Organisme : NIDDK NIH HHS
ID : F32 DK126432
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK101043
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK099511
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK036836
Pays : United States
Organisme : NIDDK NIH HHS
ID : K23 DK114550
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2021 by the American Diabetes Association.
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