Matched Targeted Therapy for Pediatric Patients with Relapsed, Refractory, or High-Risk Leukemias: A Report from the LEAP Consortium.
Journal
Cancer discovery
ISSN: 2159-8290
Titre abrégé: Cancer Discov
Pays: United States
ID NLM: 101561693
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
received:
04
05
2020
revised:
25
11
2020
accepted:
14
01
2021
pubmed:
11
2
2021
medline:
19
2
2022
entrez:
10
2
2021
Statut:
ppublish
Résumé
Despite a remarkable increase in the genomic profiling of cancer, integration of genomic discoveries into clinical care has lagged behind. We report the feasibility of rapid identification of targetable mutations in 153 pediatric patients with relapsed/refractory or high-risk leukemias enrolled on a prospective clinical trial conducted by the LEAP Consortium. Eighteen percent of patients had a high confidence Tier 1 or 2 recommendation. We describe clinical responses in the 14% of patients with relapsed/refractory leukemia who received the matched targeted therapy. Further, in order to inform future targeted therapy for patients, we validated variants of uncertain significance, performed
Identifiants
pubmed: 33563661
pii: 2159-8290.CD-20-0564
doi: 10.1158/2159-8290.CD-20-0564
pmc: PMC8178162
mid: NIHMS1667659
doi:
Substances chimiques
Biomarkers, Tumor
0
Types de publication
Clinical Trial
Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1424-1439Subventions
Organisme : NCI NIH HHS
ID : P50 CA206963
Pays : United States
Organisme : NCI NIH HHS
ID : K08 CA184418
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA214428
Pays : United States
Organisme : NCI NIH HHS
ID : R35 CA210030
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA128583
Pays : United States
Organisme : NCI NIH HHS
ID : K08 CA222684
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA232486
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA046934
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
©2021 American Association for Cancer Research.
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