Novel urinary glycan profiling by lectin array serves as the biomarkers for predicting renal prognosis in patients with IgA nephropathy.


Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
09 02 2021
Historique:
received: 07 06 2020
accepted: 17 11 2020
entrez: 10 2 2021
pubmed: 11 2 2021
medline: 12 11 2021
Statut: epublish

Résumé

In IgA nephropathy (IgAN), IgA1 molecules are characterized by galactose deficiency in O-glycans. Here, we investigated the association between urinary glycosylation profile measured by 45 lectins at baseline and renal prognosis in 142 patients with IgAN. The primary outcome was estimated glomerular filtration rate (eGFR) decline (> 4 mL/min/1.73 m

Identifiants

pubmed: 33564009
doi: 10.1038/s41598-020-77736-1
pii: 10.1038/s41598-020-77736-1
pmc: PMC7873239
doi:

Substances chimiques

Biomarkers 0
Glycoproteins 0
Lectins 0

Types de publication

Clinical Trial Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

3394

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Auteurs

Chieko Kawakita (C)

Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan.

Koki Mise (K)

Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan. kokims-frz@okayama-u.ac.jp.

Yasuhiro Onishi (Y)

Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan.

Hitoshi Sugiyama (H)

Department of Human Resource Development of Dialysis Therapy for Kidney Disease, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.

Michihiro Yoshida (M)

Center for Innovative Clinical Medicine, Okayama University Hospital, Okayama, Japan.

Masao Yamada (M)

GlycoTechnica Ltd, Yokohama, Japan.

Jun Wada (J)

Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan. junwada@okayama-u.ac.jp.

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