Total synthesis of decarboxyaltenusin.
Suzuki coupling
biaryls
boronates
mycotoxins
polyketides
Journal
Beilstein journal of organic chemistry
ISSN: 1860-5397
Titre abrégé: Beilstein J Org Chem
Pays: Germany
ID NLM: 101250746
Informations de publication
Date de publication:
2021
2021
Historique:
received:
24
11
2020
accepted:
13
01
2021
entrez:
10
2
2021
pubmed:
11
2
2021
medline:
11
2
2021
Statut:
epublish
Résumé
The total synthesis of decarboxyaltenusin (5'-methoxy-6-methyl-[1,1'-biphenyl]-3,3',4-triol), a toxin produced by various mold fungi, has been achieved in seven steps in a yield of 31% starting from 4-methylcatechol and 1-bromo-3,5-dimethoxybenzene, where the longest linear sequence consists of five steps. The key reaction was a palladium-catalyzed Suzuki coupling of an aromatic boronate with a brominated resorcin derivative.
Identifiants
pubmed: 33564332
doi: 10.3762/bjoc.17.22
pmc: PMC7849237
doi:
Types de publication
Journal Article
Langues
eng
Pagination
224-228Informations de copyright
Copyright © 2021, Warmuth et al.
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