Serum uromodulin and decline of kidney function in older participants of the population-based KORA F4/FF4 study.
albuminuria
eGFR
general community
serum uromodulin
Journal
Clinical kidney journal
ISSN: 2048-8505
Titre abrégé: Clin Kidney J
Pays: England
ID NLM: 101579321
Informations de publication
Date de publication:
Jan 2021
Jan 2021
Historique:
received:
27
08
2019
accepted:
14
02
2020
entrez:
10
2
2021
pubmed:
11
2
2021
medline:
11
2
2021
Statut:
epublish
Résumé
Uromodulin, a tissue-specific tubular glycoprotein, has recently emerged as a promising biomarker for kidney function and tubular integrity. However, the association of serum uromodulin (sUmod) with renal function decline is still unknown in an older general population. We analysed the association of sUmod with the estimated glomerular filtration rate (eGFR) and albuminuria in 1075 participants of the population-based Cooperative Health Research in the Region of Augsburg (KORA) F4 study, ages 62-81 years, at baseline and prospectively after a mean follow-up time of 6.5 years ( Cross-sectionally, sUmod was positively associated with eGFR (β = 0.31 ± 0.02 per higher standard deviation sUmod; P < 0.001) and inversely associated with the urinary albumin:creatinine ratio (β = -0.19 ± 0.04; P < 0.001) after adjustment for sex, age, body mass index, arterial hypertension, prediabetes and diabetes. After multivariable adjustment including baseline eGFR, sUmod was not associated with incident chronic kidney disease (CKD), defined as a decrease in eGFR <60 mL/min/1.73 m Higher sUmod was inversely associated with progression to advanced kidney disease but does not provide additional predictive value for the development of CKD in elderly participants of the population-based KORA study.
Sections du résumé
BACKGROUND
BACKGROUND
Uromodulin, a tissue-specific tubular glycoprotein, has recently emerged as a promising biomarker for kidney function and tubular integrity. However, the association of serum uromodulin (sUmod) with renal function decline is still unknown in an older general population.
METHODS
METHODS
We analysed the association of sUmod with the estimated glomerular filtration rate (eGFR) and albuminuria in 1075 participants of the population-based Cooperative Health Research in the Region of Augsburg (KORA) F4 study, ages 62-81 years, at baseline and prospectively after a mean follow-up time of 6.5 years (
RESULTS
RESULTS
Cross-sectionally, sUmod was positively associated with eGFR (β = 0.31 ± 0.02 per higher standard deviation sUmod; P < 0.001) and inversely associated with the urinary albumin:creatinine ratio (β = -0.19 ± 0.04; P < 0.001) after adjustment for sex, age, body mass index, arterial hypertension, prediabetes and diabetes. After multivariable adjustment including baseline eGFR, sUmod was not associated with incident chronic kidney disease (CKD), defined as a decrease in eGFR <60 mL/min/1.73 m
CONCLUSIONS
CONCLUSIONS
Higher sUmod was inversely associated with progression to advanced kidney disease but does not provide additional predictive value for the development of CKD in elderly participants of the population-based KORA study.
Identifiants
pubmed: 33564420
doi: 10.1093/ckj/sfaa032
pii: sfaa032
pmc: PMC7857794
doi:
Types de publication
Journal Article
Langues
eng
Pagination
205-211Informations de copyright
© The Author(s) 2020. Published by Oxford University Press on behalf of ERA-EDTA.
Références
Eur J Clin Invest. 2005 Apr;35(4):227-35
pubmed: 15816991
J Am Soc Nephrol. 2003 Nov;14(11):2883-93
pubmed: 14569098
J Clin Endocrinol Metab. 2019 Mar 20;:
pubmed: 30892596
N Engl J Med. 2012 Jul 5;367(1):20-9
pubmed: 22762315
J Am Soc Nephrol. 2017 Jul;28(7):2201-2210
pubmed: 28242751
BMC Med Genet. 2012 Sep 05;13:78
pubmed: 22947327
J Med Genet. 2002 Dec;39(12):882-92
pubmed: 12471200
Diabetes Care. 2011 Jul;34(7):1648-50
pubmed: 21617096
Gesundheitswesen. 2005 Aug;67 Suppl 1:S19-25
pubmed: 16032513
Eur J Endocrinol. 2012 Dec;167(6):847-53
pubmed: 23002189
Nephron. 2000 Jul;85(3):207-14
pubmed: 10867535
Kidney Int. 2014 Sep;86(3):589-99
pubmed: 24670410
Clin J Am Soc Nephrol. 2018 Oct 8;13(10):1556-1557
pubmed: 30054352
J Am Soc Nephrol. 2010 Feb;21(2):337-44
pubmed: 19959715
J Hypertens. 2018 Jan;36(1):110-118
pubmed: 28858977
Nephrol Dial Transplant. 2014 Jan;29(1):136-45
pubmed: 24097801
Am J Kidney Dis. 2019 Oct;74(4):501-509
pubmed: 31128770
Am J Physiol Renal Physiol. 2013 Apr 15;304(8):F1066-75
pubmed: 23389456
Kidney Int. 2004 Mar;65(3):791-7
pubmed: 14871399
Clin Nephrol. 2019 Apr;91(4):254-264
pubmed: 30686288
Kidney Int. 2015 Nov;88(5):1126-34
pubmed: 26154925
Kidney Blood Press Res. 2010;33(5):393-8
pubmed: 20948228
Semin Nephrol. 2010 Jul;30(4):366-73
pubmed: 20807609
J Am Soc Nephrol. 2014 Aug;25(8):1869-82
pubmed: 24578125
Mol Biol Cell. 2009 Jan;20(2):589-99
pubmed: 19005207
Nephrol Dial Transplant. 2018 Feb 1;33(2):284-295
pubmed: 28206617
J Transl Med. 2018 Nov 19;16(1):316
pubmed: 30454063
Clin Nephrol. 2017 Jun;87(6):278-286
pubmed: 28332475
Nat Rev Nephrol. 2017 Sep;13(9):525-544
pubmed: 28781372
Clin Chem Lab Med. 2014 Dec;52(12):1755-61
pubmed: 24933630
Biochem Biophys Res Commun. 2001 Jan 12;280(1):110-4
pubmed: 11162486
Glycoconj J. 2005 Nov;22(7-9):383-94
pubmed: 16622944
Clin Sci (Lond). 1985 May;68(5):529-35
pubmed: 3979015
J Urol. 2009 May;181(5):2332-8
pubmed: 19303096
J Am Soc Nephrol. 2012 Nov;23(11):1783-9
pubmed: 22997256
Am J Nephrol. 2018;47(4):275-282
pubmed: 29698955
Hum Mol Genet. 2009 Aug 15;18(16):2963-74
pubmed: 19465746
Infect Immun. 2002 May;70(5):2650-6
pubmed: 11953407
Curr Opin Nephrol Hypertens. 2017 Mar;26(2):136-142
pubmed: 27898524
J Biol Chem. 2001 Mar 30;276(13):9924-30
pubmed: 11134021
Medicine (Baltimore). 2016 Mar;95(10):e3011
pubmed: 26962815
Urol Res. 2004 May;32(2):79-83
pubmed: 15250099
Endocr Connect. 2019 Oct;8(10):1363-1371
pubmed: 31505464
Diabet Med. 2009 Dec;26(12):1212-9
pubmed: 20002472
Medicine (Baltimore). 2017 Feb;96(5):e5798
pubmed: 28151855