The non-coding epitranscriptome in cancer.
RNA epigenetics
RNA methylation
RNA modifications
cancer
epitranscriptomics
non-coding RNA
Journal
Briefings in functional genomics
ISSN: 2041-2657
Titre abrégé: Brief Funct Genomics
Pays: England
ID NLM: 101528229
Informations de publication
Date de publication:
27 03 2021
27 03 2021
Historique:
pubmed:
11
2
2021
medline:
26
10
2021
entrez:
10
2
2021
Statut:
ppublish
Résumé
Post-synthesis modification of biomolecules is an efficient way of regulating and optimizing their functions. The human epitranscriptome includes a variety of more than 100 modifications known to exist in all RNA subtypes. Modifications of non-coding RNAs are particularly interesting since they can directly affect their structure, stability, interaction and function. Indeed, non-coding RNAs such as tRNA and rRNA are the most modified RNA species in eukaryotic cells. In the last 20 years, new functions of non-coding RNAs have been discovered and their involvement in human disease, including cancer, became clear. In this review, we will present the evidence connecting modifications of different non-coding RNA subtypes and their role in cancer.
Identifiants
pubmed: 33564819
pii: 6131979
doi: 10.1093/bfgp/elab003
pmc: PMC8479548
doi:
Substances chimiques
RNA
63231-63-0
RNA, Transfer
9014-25-9
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
94-105Informations de copyright
© The Author(s) 2021. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
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