Regulation of Chlamydia spreading from the small intestine to the large intestine via an immunological barrier.
Chlamydia
CD4+ T cells
intestinal barrier
Journal
Immunology and cell biology
ISSN: 1440-1711
Titre abrégé: Immunol Cell Biol
Pays: United States
ID NLM: 8706300
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
revised:
29
11
2020
revised:
13
01
2021
revised:
03
02
2021
received:
18
08
2020
accepted:
08
02
2021
pubmed:
11
2
2021
medline:
29
9
2021
entrez:
10
2
2021
Statut:
ppublish
Résumé
The obligate intracellular bacterium Chlamydia is a genital tract pathogen that can also colonize the gastrointestinal tract for long periods. The long-lasting colonization is dependent on chlamydial spreading from the small intestine to the large intestine. We previously reported that a mutant Chlamydia was able to activate an intestinal barrier for blocking its own spreading to the large intestine. In the current study, we used the mutant Chlamydia colonization model to confirm the intestinal barrier function and further to determine the immunological basis of the barrier with gene-deficient mice. Recombination activating gene 1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
611-621Subventions
Organisme : NIAID NIH HHS
ID : R01 AI121989
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI064537
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI057450
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI047997
Pays : United States
Informations de copyright
© 2021 Australian and New Zealand Society for Immunology Inc.
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