Gastric emptying of solutions containing the natural sweetener erythritol and effects on gut hormone secretion in humans: A pilot dose-ranging study.
appetite-related sensations
blood lipids
erythritol
gastric emptying
gastrointestinal symptoms
gut hormones
natural sweeteners
uric acid
Journal
Diabetes, obesity & metabolism
ISSN: 1463-1326
Titre abrégé: Diabetes Obes Metab
Pays: England
ID NLM: 100883645
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
revised:
28
01
2021
received:
30
11
2020
accepted:
04
02
2021
pubmed:
11
2
2021
medline:
10
7
2021
entrez:
10
2
2021
Statut:
ppublish
Résumé
To determine whether a dose-dependent effect in the stimulation of gut hormone release (plasma cholecystokinin [CCK], active glucagon-like peptide-1 [aGLP-1] and peptide tyrosine tyrosine [PYY]) is found for the natural sweetener erythritol. Twelve healthy, lean volunteers received solutions with 10, 25 or 50 g erythritol, or tap water enriched with We found (a) a dose-dependent stimulation of CCK, aGLP-1 and PYY, and slowing of GE, (b) no effect on blood glucose, insulin, motilin, glucagon or glucose-dependent insulinotropic polypeptide, (c) no effect on blood lipids and uric acid, and (d) no abdominal pain, nausea or vomiting. Solutions with 10 and 50 g of erythritol stimulated gut hormone release. Emptying of erythritol-containing solutions from the stomach was slower compared with placebo. There was no effect on plasma glucose, insulin, glucagon, blood lipids or uric acid. All doses were well tolerated.
Identifiants
pubmed: 33565706
doi: 10.1111/dom.14342
pmc: PMC8247993
doi:
Substances chimiques
Blood Glucose
0
Gastrointestinal Hormones
0
Insulin
0
Sweetening Agents
0
Glucagon
9007-92-5
Cholecystokinin
9011-97-6
Erythritol
RA96B954X6
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1311-1321Informations de copyright
© 2021 The Authors. Diabetes, Obesity and Metabolism published by John Wiley & Sons Ltd.
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