Safety and immunogenicity of adjuvanted recombinant subunit herpes zoster vaccine in lung transplant recipients.
clinical research/practice
complication: infectious
infection and infectious agents - viral
infectious disease
lung transplantation/pulmonology
translational research/ science
vaccine
Journal
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
ISSN: 1600-6143
Titre abrégé: Am J Transplant
Pays: United States
ID NLM: 100968638
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
revised:
26
01
2021
received:
13
12
2020
accepted:
28
01
2021
pubmed:
11
2
2021
medline:
29
6
2021
entrez:
10
2
2021
Statut:
ppublish
Résumé
Lung transplant recipients are at high risk for herpes zoster and preventive measures are a significant unmet need. We investigated the safety and immunogenicity of two doses of a recombinant zoster vaccine (RZV) in lung transplant recipients (≥50 years). We enrolled 50 patients of which 49 received at least one vaccine dose. Anti-glycoprotein E (gE) antibody levels (n = 43) increased significantly compared to baseline (median optical density [OD] 1.96; interquartile range [IQR]: 1.17-2.89) after the first (median OD 3.41, IQR 2.54-3.81, p < .0001) and second vaccine dose (median OD 3.63, IQR 3.39-3.86, p < .0001). gE-specific polyfunctional CD4+ T cell frequencies (n = 38) also increased from baseline (median 85 per 10
Identifiants
pubmed: 33565711
doi: 10.1111/ajt.16534
pmc: PMC9169546
mid: NIHMS1805272
pii: S1600-6135(22)08599-9
doi:
Substances chimiques
Antibodies, Viral
0
Herpes Zoster Vaccine
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2246-2253Subventions
Organisme : Intramural CDC HHS
ID : CC999999
Pays : United States
Informations de copyright
© 2021 The American Society of Transplantation and the American Society of Transplant Surgeons.
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