Pyrrolopyrimidine Bumped Kinase Inhibitors for the Treatment of Cryptosporidiosis.

Animals Antiprotozoal Agents Cryptosporidiosis / drug therapy Cryptosporidium Mice Protein Kinase Inhibitors / pharmacology Pyrimidines Pyrroles
Cryptosporidium bumped kinase inhibitors cryptosporidiosis pyrazolopyrimidines pyrrolopyrimidines

Journal

ACS infectious diseases
ISSN: 2373-8227
Titre abrégé: ACS Infect Dis
Pays: United States
ID NLM: 101654580

Informations de publication

Date de publication:
14 05 2021
Historique:
pubmed: 11 2 2021
medline: 24 6 2021
entrez: 10 2 2021
Statut: ppublish

Résumé

Bumped kinase inhibitors (BKIs) that target

Identifiants

DOI: 10.1021/acsinfecdis.0c00803 PMID: 33565854 PMC: PMC8559537
pubmed: 33565854
doi: 10.1021/acsinfecdis.0c00803
pmc: PMC8559537
mid: NIHMS1750630
doi:

Substances chimiques

Antiprotozoal Agents 0
Protein Kinase Inhibitors 0
Pyrimidines 0
Pyrroles 0
pyrrolopyrimidine 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

1200-1207

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI155412
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI089441
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI112427
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI111341
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD080670
Pays : United States
Organisme : BLRD VA
ID : IK2 BX002440
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI123690
Pays : United States

Références

J Pharmacol Toxicol Methods. 2016 Nov - Dec;82:62-67
pubmed: 27432021
J Biol Chem. 2015 Feb 20;290(8):4573-4589
pubmed: 25552479
Nature. 2017 Jun 15;546(7658):376-380
pubmed: 28562588
Lancet. 2013 Jul 20;382(9888):209-22
pubmed: 23680352
Front Pharmacol. 2014 Sep 02;5:203
pubmed: 25228880
Antimicrob Agents Chemother. 2018 Mar 27;62(4):
pubmed: 29339392
PLoS One. 2016 Sep 30;11(9):e0158772
pubmed: 27690129
Mutat Res. 2012 Aug 30;747(1):36-45
pubmed: 22579797
Int J Parasitol. 2017 Oct;47(12):753-763
pubmed: 28899690
J Med Chem. 2019 Mar 28;62(6):3135-3146
pubmed: 30830766
Antimicrob Agents Chemother. 2019 Mar 27;63(4):
pubmed: 30745384
J Clin Invest. 2012 Jun;122(6):2301-5
pubmed: 22565309
Proc Natl Acad Sci U S A. 2019 Apr 2;116(14):7015-7020
pubmed: 30894487
J Biol Chem. 2001 Apr 13;276(15):12369-77
pubmed: 11154702
ACS Med Chem Lett. 2014 Jan 9;5(1):40-44
pubmed: 24494061
ACS Infect Dis. 2018 Apr 13;4(4):516-522
pubmed: 29522315
J Infect Dis. 2017 Jul 1;216(1):55-63
pubmed: 28541457
Environ Mol Mutagen. 2011 Jun;52(5):355-62
pubmed: 20963813
EMBO J. 2012 Dec 12;31(24):4524-34
pubmed: 23149386
PLoS Negl Trop Dis. 2018 Aug 6;12(8):e0006673
pubmed: 30080847
J Infect Dis. 2016 Dec 15;214(12):1856-1864
pubmed: 27923949
PLoS Negl Trop Dis. 2017 Feb 3;11(2):e0005373
pubmed: 28158186
Lancet Infect Dis. 2015 Jan;15(1):85-94
pubmed: 25278220
N Engl J Med. 1994 Jul 21;331(3):161-7
pubmed: 7818640
J Infect Dis. 2017 Apr 15;215(8):1275-1284
pubmed: 28329187
J Infect Dis. 2014 Jan 15;209(2):275-84
pubmed: 24123773
Int J Biol Sci. 2017 May 16;13(6):748-758
pubmed: 28656000
J Med Chem. 2014 Feb 13;57(3):828-35
pubmed: 24354316
J Med Chem. 2016 Jul 14;59(13):6531-46
pubmed: 27309760
Lancet. 2002 Nov 2;360(9343):1375-80
pubmed: 12423984
ACS Med Chem Lett. 2010 Oct 14;1(7):331-335
pubmed: 21116453
PLoS One. 2016 Mar 29;11(3):e0152300
pubmed: 27023625
Curr Trop Med Rep. 2015 Sep;2(3):181-187
pubmed: 26568906
Nat Commun. 2019 Jun 27;10(1):2816
pubmed: 31249291
Nat Struct Mol Biol. 2010 May;17(5):602-7
pubmed: 20436472
Proc Natl Acad Sci U S A. 2018 Oct 16;115(42):10750-10755
pubmed: 30282735
J Infect Dis. 2013 Oct 15;208(8):1342-8
pubmed: 23878324
Int J Biochem Cell Biol. 2005 Aug;37(8):1572-7
pubmed: 15896667
Chem Biol. 2015 Sep 17;22(9):1174-84
pubmed: 26320862
Antimicrob Agents Chemother. 2018 Jun 26;62(7):
pubmed: 29661877
Lancet Glob Health. 2015 Sep;3(9):e564-75
pubmed: 26202075
Nature. 2015 Jul 23;523(7561):477-80
pubmed: 26176919
J Infect Dis. 2016 Dec 15;214(12):1850-1855
pubmed: 27738055
J Infect Dis. 2001 Jul 1;184(1):103-6
pubmed: 11398117
Antimicrob Agents Chemother. 2017 Jul 25;61(8):
pubmed: 28533246

Auteurs

Matthew A Hulverson (MA)

Department of Medicine, Division of Allergy and Infectious Disease, Center for Emerging and Re-emerging Infectious Disease (CERID), University of Washington, Seattle, Washington 98109, United States.
ORCID: 0000-0002-3413-4969

Ryan Choi (R)

Department of Medicine, Division of Allergy and Infectious Disease, Center for Emerging and Re-emerging Infectious Disease (CERID), University of Washington, Seattle, Washington 98109, United States.

Rama S R Vidadala (RSR)

Department of Chemistry, University of Washington, Seattle, Washington 98195, United States.

Grant R Whitman (GR)

Department of Medicine, Division of Allergy and Infectious Disease, Center for Emerging and Re-emerging Infectious Disease (CERID), University of Washington, Seattle, Washington 98109, United States.

Venkata Narayana Vidadala (VN)

Department of Chemistry, University of Washington, Seattle, Washington 98195, United States.

Kayode K Ojo (KK)

Department of Medicine, Division of Allergy and Infectious Disease, Center for Emerging and Re-emerging Infectious Disease (CERID), University of Washington, Seattle, Washington 98109, United States.
ORCID: 0000-0002-2007-2170

Lynn K Barrett (LK)

Department of Medicine, Division of Allergy and Infectious Disease, Center for Emerging and Re-emerging Infectious Disease (CERID), University of Washington, Seattle, Washington 98109, United States.

James J Lynch (JJ)

Research and Development, AbbVie Inc., North Chicago, Illinois 60064, United States.

Kennan Marsh (K)

Research and Development, AbbVie Inc., North Chicago, Illinois 60064, United States.

Dale J Kempf (DJ)

Research and Development, AbbVie Inc., North Chicago, Illinois 60064, United States.
ORCID: 0000-0002-1408-9099

Dustin J Maly (DJ)

Department of Chemistry, University of Washington, Seattle, Washington 98195, United States.
Department of Biochemistry, University of Washington, Seattle, Washington 98195, United States.
ORCID: 0000-0003-0094-0177

Wesley C Van Voorhis (WC)

Department of Medicine, Division of Allergy and Infectious Disease, Center for Emerging and Re-emerging Infectious Disease (CERID), University of Washington, Seattle, Washington 98109, United States.

Articles similaires

Evaluating the efficacy of telesurgery with dual console SSI Mantra Surgical Robotic System: experiment on animal model and clinical trials.

Sudhir Prem Srivastava, Vishwajyoti Pascual Srivastava, Avinesh Singh et al.
1.00
Robotic Surgical Procedures Animals Humans Telemedicine Models, Animal

Odour generalisation and detection dog training.

Lyn Caldicott, Thomas W Pike, Helen E Zulch et al.
1.00
Animals Odorants Dogs Generalization, Psychological Smell

FBXO22 inhibits colitis and colorectal carcinogenesis by regulating the degradation of the S2448-phosphorylated form of mTOR.

Minle Li, Xuan Chen, Pengfei Qu et al.
1.00
Animals TOR Serine-Threonine Kinases Colorectal Neoplasms Colitis Mice

Use of organic material provided by an automatic enrichment device by weaner pigs and its influence on tail lesions.

Philipp Heseker, Jeanette Probst, Stefanie Ammer et al.
1.00
Animals Tail Swine Behavior, Animal Animal Husbandry

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Pyrrolopyrimidine Bumped Kinase Inhibitors for...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiparasitaires › Antiprotozoaires › Pyrrolopyrimidine Bumped Kinase Inhibitors for...
questionsmedicales.fr › Maladies de l'animal › Parasitoses animales › Protozooses animales › Cryptosporidiose › Pyrrolopyrimidine Bumped Kinase Inhibitors for...
questionsmedicales.fr › Eucaryotes › Alveolata › Apicomplexa › Coccidia › Eimeriida › Cryptosporidiidae › Cryptosporidium › Pyrrolopyrimidine Bumped Kinase Inhibitors for...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Pyrrolopyrimidine Bumped Kinase Inhibitors for...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Inhibiteurs de protéines kinases › Pyrrolopyrimidine Bumped Kinase Inhibitors for...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyrimidines › Pyrrolopyrimidine Bumped Kinase Inhibitors for...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Pyrroles › Pyrrolopyrimidine Bumped Kinase Inhibitors for...