X-ray phase contrast tomography for the investigation of amyotrophic lateral sclerosis.
ALS
X-ray phase contrast tomography
spinal cord
Journal
Journal of synchrotron radiation
ISSN: 1600-5775
Titre abrégé: J Synchrotron Radiat
Pays: United States
ID NLM: 9888878
Informations de publication
Date de publication:
01 Jul 2020
01 Jul 2020
Historique:
received:
29
07
2019
accepted:
20
05
2020
entrez:
10
2
2021
pubmed:
11
2
2021
medline:
27
8
2021
Statut:
ppublish
Résumé
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder affecting motor neurons. Pre-clinical studies drive the development of animal models that well mimic ALS disorder and enable both the dissection of disease processes and an early assessment of therapy efficacy. A comprehensive knowledge of neuronal and vascular lesions in the brain and spinal cord is an essential factor to understand the development of the disease. Spatial resolution and bidimensional imaging are important drawbacks limiting current neuroimaging tools, while neuropathology relies on protocols that may alter tissue chemistry and structure. In contrast, recent ex vivo studies in mice demonstrated that X-ray phase-contrast tomography enables study of the 3D distribution of both vasculature and neuronal networks, without sample sectioning or use of staining. Here we present our findings on ex vivo SOD1
Identifiants
pubmed: 33566014
pii: S1600577520006785
doi: 10.1107/S1600577520006785
pmc: PMC7336179
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1042-1048Informations de copyright
open access.
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