Early and sustained Lactobacillus plantarum probiotic therapy in critical illness: the randomised, placebo-controlled, restoration of gut microflora in critical illness trial (ROCIT).
Critical illness
Intensive care unit
Nosocomial infection
Probiotics
Journal
Intensive care medicine
ISSN: 1432-1238
Titre abrégé: Intensive Care Med
Pays: United States
ID NLM: 7704851
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
received:
19
09
2020
accepted:
07
11
2020
pubmed:
11
2
2021
medline:
1
6
2021
entrez:
10
2
2021
Statut:
ppublish
Résumé
In adults requiring treatment in an intensive care unit, probiotic therapy using Lactobacillus plantarum 299v may reduce nosocomial infection. The aim of this study was to determine whether early and sustained L. plantarum 299v therapy administered to adult ICU patients increased days alive and at home. A multicentre, parallel group, placebo-controlled, randomised clinical trial was conducted. Adult patients within 48 h of intensive care admission and expected to require intensive care beyond the day after recruitment were eligible to participate. L plantarum 299v or placebo were administered immediately after enrolment and continued for 60 days. The primary outcome was days alive and out of hospital to Day 60 (DAOH The median [interquartile range (IQR)] number of DAOH Early and sustained untargeted administration of probiotic therapy with Lactobacillus plantarum 299v to adult patients admitted to the ICU is safe, but not associated with improved patient outcomes.
Identifiants
pubmed: 33566129
doi: 10.1007/s00134-020-06322-w
pii: 10.1007/s00134-020-06322-w
pmc: PMC7873510
doi:
Types de publication
Journal Article
Multicenter Study
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
307-315Subventions
Organisme : Government of Western Australia
ID : Research Translation Project 2016 (Round 10)
Commentaires et corrections
Type : CommentIn
Type : CommentIn
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