The Association Between β-Dystroglycan in Airway Smooth Muscle and Eosinophils in Allergic Asthma.
airway smooth muscle
allergic asthma
eosinophil
inflammation
remodeling
β-dystroglycan
Journal
Inflammation
ISSN: 1573-2576
Titre abrégé: Inflammation
Pays: United States
ID NLM: 7600105
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
received:
08
12
2019
accepted:
09
12
2020
revised:
07
12
2020
pubmed:
11
2
2021
medline:
15
12
2021
entrez:
10
2
2021
Statut:
ppublish
Résumé
Allergic asthma (AA) is a complex disorder with heterogeneous features of airway hyperresponsiveness, inflammation, and remodeling. The increase of airway smooth muscle (ASM) mass is a fundamental component of bronchial remodeling in AA, yet the pathophysiological mechanisms and clinical outcomes associated with ASM modulation are still elusive. The objective of this study is to compare the expression level of β-dystroglycan (β-DG) in ASM in AA subjects and a healthy control group and to investigate the relationship between eosinophils and β-DG in ASM in patients with AA. Thirteen AA patients and seven control subjects were analyzed for the ASM area and eosinophil cells. Bronchial biopsies were stained by β-DG and eosinophil cationic protein (ECP) using immunohistochemistry. The proportion of ASM with β-DG staining was greater in those with AA than in the healthy control group (mean (95% CI) (28.3% (23.8-32.7%) vs. 16.4% (14.1-18.5%), P < 0.0001). The number of ECP positive cells was higher in patients with AA than in the control group (4056 (3819-4296) vs. 466 (395-537) cells/mm
Identifiants
pubmed: 33566255
doi: 10.1007/s10753-020-01401-y
pii: 10.1007/s10753-020-01401-y
pmc: PMC8139938
doi:
Substances chimiques
DAG1 protein, human
0
Dystroglycans
146888-27-9
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1060-1068Références
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