A biphasic multilayer computational model of human skin.
Biphasic material
Human skin
Hyperelasticity
Inverse analysis
Poroelastic soft tissue
Journal
Biomechanics and modeling in mechanobiology
ISSN: 1617-7940
Titre abrégé: Biomech Model Mechanobiol
Pays: Germany
ID NLM: 101135325
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
received:
11
03
2020
accepted:
12
01
2021
pubmed:
11
2
2021
medline:
15
12
2021
entrez:
10
2
2021
Statut:
ppublish
Résumé
The present study investigates the layer-specific mechanical behavior of human skin. Motivated by skin's histology, a biphasic model is proposed which differentiates between epidermis, papillary and reticular dermis, and hypodermis. Inverse analysis of ex vivo tensile and in vivo suction experiments yields mechanical parameters for each layer and predicts a stiff reticular dermis and successively softer papillary dermis, epidermis and hypodermis. Layer-specific analysis of simulations underlines the dominating role of the reticular dermis in tensile loading. Furthermore, it shows that the observed out-of-plane deflection in ex vivo tensile tests is a direct consequence of the layered structure of skin. In in vivo suction experiments, the softer upper layers strongly influence the mechanical response, whose dissipative part is determined by interstitial fluid redistribution within the tissue. Magnetic resonance imaging-based visualization of skin deformation in suction experiments confirms the deformation pattern predicted by the multilayer model, showing a consistent decrease in dermal thickness for large probe opening diameters.
Identifiants
pubmed: 33566274
doi: 10.1007/s10237-021-01424-w
pii: 10.1007/s10237-021-01424-w
pmc: PMC8154831
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
969-982Subventions
Organisme : Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
ID : 179012
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