NUPR1 protects liver from lipotoxic injury by improving the endoplasmic reticulum stress response.
NAFL
NASH
NUPR1
PPAR-a signalling
UPR
lipotoxicity
Journal
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
ISSN: 1530-6860
Titre abrégé: FASEB J
Pays: United States
ID NLM: 8804484
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
received:
02
11
2020
revised:
08
01
2021
accepted:
08
01
2021
entrez:
10
2
2021
pubmed:
11
2
2021
medline:
27
7
2021
Statut:
ppublish
Résumé
Non-alcoholic fatty liver (NAFL) and related syndromes affect one-third of the adult population in industrialized and developing countries. Lifestyle and caloric oversupply are the main causes of such array of disorders, but the molecular mechanisms underlying their etiology remain elusive. Nuclear Protein 1 (NUPR1) expression increases upon cell injury in all organs including liver. Recently, we reported NUPR1 actively participates in the activation of the Unfolded Protein Response (UPR). The UPR typically maintains protein homeostasis, but downstream mediators of the pathway regulate metabolic functions including lipid metabolism. As increases in UPR and NUPR1 in obesity and liver disease have been well documented, the goal of this study was to investigate the roles of NUPR1 in this context. To establish whether NUPR1 is involved in these liver conditions we used patient-derived liver biopsies and in vitro and in vivo NUPR1 loss of functions models. First, we analyzed NUPR1 expression in a cohort of morbidly obese patients (MOPs), with simple fatty liver (NAFL) or more severe steatohepatitis (NASH). Next, we explored the metabolic roles of NUPR1 in wild-type (Nupr1
Identifiants
pubmed: 33566371
doi: 10.1096/fj.202002413RR
doi:
Substances chimiques
Basic Helix-Loop-Helix Transcription Factors
0
NUPR1 protein, human
0
Neoplasm Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e21395Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2021 Federation of American Societies for Experimental Biology.
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