Perforin
cytokine storm
cytotoxic lymphocytes
hemophagocytic lymphohistiocytosis
inflammation
multiple sclerosis
type 1 diabetes
Journal
Multiple sclerosis (Houndmills, Basingstoke, England)
ISSN: 1477-0970
Titre abrégé: Mult Scler
Pays: England
ID NLM: 9509185
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
pubmed:
11
2
2021
medline:
1
6
2022
entrez:
10
2
2021
Statut:
ppublish
Résumé
Defective alleles within the The aim of this study was to determine the function of hypomorph We cross-compare the association data for We report that Our results indicate opposing contributions of the cytotoxic T-cell compartment to MS and T1D pathogenesis.
Sections du résumé
BACKGROUND
Defective alleles within the
OBJECTIVE
The aim of this study was to determine the function of hypomorph
METHODS
We cross-compare the association data for
RESULTS
We report that
CONCLUSION
Our results indicate opposing contributions of the cytotoxic T-cell compartment to MS and T1D pathogenesis.
Identifiants
pubmed: 33566725
doi: 10.1177/1352458520963937
pmc: PMC8044257
mid: NIHMS1629873
doi:
Substances chimiques
FHL2 protein, human
0
LIM-Homeodomain Proteins
0
Muscle Proteins
0
PRF1 protein, human
0
Transcription Factors
0
Perforin
126465-35-8
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1332-1340Subventions
Organisme : Wellcome Trust
ID : 076113
Pays : United Kingdom
Organisme : NIDA NIH HHS
ID : HHSN271201100005C
Pays : United States
Organisme : Wellcome Trust
ID : 107212
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 091157
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : NIA NIH HHS
ID : N01AG12109
Pays : United States
Organisme : Department of Health
Pays : United Kingdom
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