Fluorogenic Squaraine Dendrimers for Background-Free Imaging of Integrin Receptors in Cancer Cells.
aggregation
dendrimers
fluorescent probes
fluorogenic response
integrin receptor
Journal
Chemistry (Weinheim an der Bergstrasse, Germany)
ISSN: 1521-3765
Titre abrégé: Chemistry
Pays: Germany
ID NLM: 9513783
Informations de publication
Date de publication:
16 Apr 2021
16 Apr 2021
Historique:
received:
07
02
2021
pubmed:
11
2
2021
medline:
21
4
2021
entrez:
10
2
2021
Statut:
ppublish
Résumé
To overcome the limited brightness of existing fluorogenic molecular probes for biomolecular targets, we introduce a concept of fluorogenic dendrimer probe, which undergoes polarity-dependent switching due to intramolecular aggregation-caused quenching of its fluorophores. Based on a rational design of dendrimers with four and eight squaraine dyes, we found that octamer bearing dyes through a sufficiently long PEG(8) linker displays >400-fold fluorescence enhancement from water to non-polar dioxane. High extinction coefficient (≈2,300,000 m
Identifiants
pubmed: 33567148
doi: 10.1002/chem.202100480
doi:
Substances chimiques
Cyclobutanes
0
Dendrimers
0
Fluorescent Dyes
0
Integrins
0
Phenols
0
squaraine
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
6795-6803Subventions
Organisme : H2020 European Research Council
ID : BrightSens 648528
Organisme : Fellowship grant sponsored under Government of India
ID : F.24-51/2014
Informations de copyright
© 2021 Wiley-VCH GmbH.
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