mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants.


Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
04 2021
Historique:
received: 15 01 2021
accepted: 03 02 2021
pubmed: 11 2 2021
medline: 29 4 2021
entrez: 10 2 2021
Statut: ppublish

Résumé

Here we report on the antibody and memory B cell responses of a cohort of 20 volunteers who received the Moderna (mRNA-1273) or Pfizer-BioNTech (BNT162b2) vaccine against SARS-CoV-2

Identifiants

pubmed: 33567448
doi: 10.1038/s41586-021-03324-6
pii: 10.1038/s41586-021-03324-6
pmc: PMC8503938
mid: NIHMS1709573
doi:

Substances chimiques

Antibodies, Monoclonal 0
Antibodies, Neutralizing 0
Antibodies, Viral 0
COVID-19 Vaccines 0
Epitopes, B-Lymphocyte 0
Immunoglobulin G 0
Immunoglobulin M 0
Spike Glycoprotein, Coronavirus 0
Vaccines, Synthetic 0
spike protein, SARS-CoV-2 0
2019-nCoV Vaccine mRNA-1273 EPK39PL4R4
BNT162 Vaccine N38TVC63NU

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

616-622

Subventions

Organisme : NIH HHS
ID : P50 AI150464-13
Pays : United States
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : NIAID NIH HHS
ID : R01 AI078788
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI138938
Pays : United States
Organisme : NIH HHS
ID : R01 AI78788
Pays : United States
Organisme : NIAID NIH HHS
ID : R37 AI064003
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI111825
Pays : United States
Organisme : NIAID NIH HHS
ID : P50 AI150464
Pays : United States
Organisme : NIH HHS
ID : P01 AI138398-S1
Pays : United States
Organisme : Howard Hughes Medical Institute
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001866
Pays : United States
Organisme : NIH HHS
ID : 2U19AI111825
Pays : United States

Commentaires et corrections

Type : UpdateOf
Type : CommentIn

Références

Cell. 2020 Jul 9;182(1):73-84.e16
pubmed: 32425270
PLoS Pathog. 2021 Apr 8;17(4):e1009453
pubmed: 33831132
Nature. 2020 Aug;584(7821):450-456
pubmed: 32698192
Nat Methods. 2018 Nov;15(11):905-908
pubmed: 30377346
Cell Host Microbe. 2021 Mar 10;29(3):463-476.e6
pubmed: 33592168
Nat Med. 2021 Apr;27(4):620-621
pubmed: 33558724
J Virol. 2021 Mar 1;95(10):
pubmed: 33649194
N Engl J Med. 2021 Jan 21;384(3):238-251
pubmed: 33332778
Science. 2020 Aug 7;369(6504):643-650
pubmed: 32540902
JAMA. 2021 Feb 9;325(6):529-531
pubmed: 33404586
N Engl J Med. 2021 Jan 7;384(1):80-82
pubmed: 33270381
Nature. 2020 Dec;588(7838):498-502
pubmed: 32805734
Nature. 2020 Aug;584(7821):437-442
pubmed: 32555388
Elife. 2020 Oct 28;9:
pubmed: 33112236
Science. 2021 Feb 19;371(6531):850-854
pubmed: 33495308
PLoS One. 2012;7(11):e49774
pubmed: 23226220
N Engl J Med. 2020 Oct 15;383(16):1544-1555
pubmed: 32722908
J Exp Med. 2020 Nov 2;217(11):
pubmed: 32692348
Nature. 2021 May;593(7857):142-146
pubmed: 33780970
Nature. 2020 Jul;583(7815):290-295
pubmed: 32422645
Nat Med. 2021 Apr;27(4):622-625
pubmed: 33654292
Nature. 2020 Oct;586(7830):594-599
pubmed: 32998157
Nat Med. 2020 Jul;26(7):1033-1036
pubmed: 32398876
N Engl J Med. 2020 Nov 12;383(20):1920-1931
pubmed: 32663912
Nat Methods. 2017 Mar;14(3):290-296
pubmed: 28165473
Cell. 2020 Jun 25;181(7):1489-1501.e15
pubmed: 32473127
Science. 2021 Feb 12;371(6530):735-741
pubmed: 33436524
Proc Natl Acad Sci U S A. 2021 Sep 7;118(36):
pubmed: 34417349
J Mol Biol. 1982 May 5;157(1):105-32
pubmed: 7108955
Science. 2020 Sep 18;369(6510):1501-1505
pubmed: 32703906
Science. 2020 Aug 21;369(6506):1014-1018
pubmed: 32540904
Nature. 2019 Feb;566(7744):398-402
pubmed: 30760926
Nature. 2020 Aug;584(7819):115-119
pubmed: 32454513
Biophys J. 1985 Jan;47(1):61-70
pubmed: 3978191
Nature. 2020 Oct;586(7830):501-502
pubmed: 33077943
Science. 2020 Aug 21;369(6506):956-963
pubmed: 32540903
Science. 2020 Nov 27;370(6520):1110-1115
pubmed: 33037066
Nature. 2021 Mar;591(7851):639-644
pubmed: 33461210
Acta Crystallogr D Biol Crystallogr. 2010 Apr;66(Pt 4):486-501
pubmed: 20383002
Cell. 2021 Mar 4;184(5):1171-1187.e20
pubmed: 33621484
Science. 2020 Nov 20;370(6519):950-957
pubmed: 32972994
Cell Host Microbe. 2021 Jan 13;29(1):44-57.e9
pubmed: 33259788
Nature. 2020 Aug;584(7821):443-449
pubmed: 32668443
J Struct Biol. 2005 Oct;152(1):36-51
pubmed: 16182563
Bioinformatics. 2015 Oct 15;31(20):3356-8
pubmed: 26069265
J Exp Med. 2021 Mar 1;218(3):
pubmed: 33211088
N Engl J Med. 2007 Nov 8;357(19):1903-15
pubmed: 17989383
Nature. 2020 Oct;586(7830):516-527
pubmed: 32967006
Front Immunol. 2019 Oct 09;10:2365
pubmed: 31649674
Cell. 2020 Sep 3;182(5):1284-1294.e9
pubmed: 32730807
Nature. 2020 Dec;588(7839):682-687
pubmed: 33045718
Nature. 2019 Feb;566(7744):393-397
pubmed: 30664748
Nature. 2018 Sep;561(7724):479-484
pubmed: 30258136
Nat Med. 2018 Nov;24(11):1701-1707
pubmed: 30258217
Glob Chall. 2017 Jan 10;1(1):33-46
pubmed: 31565258
PLoS One. 2016 Aug 11;11(8):e0160853
pubmed: 27513338
Cell. 2020 Aug 20;182(4):828-842.e16
pubmed: 32645326
Cell. 2020 Nov 12;183(4):1024-1042.e21
pubmed: 32991844
N Engl J Med. 2020 Dec 31;383(27):2603-2615
pubmed: 33301246
Protein Sci. 2018 Jan;27(1):14-25
pubmed: 28710774
N Engl J Med. 2020 Dec 17;383(25):2439-2450
pubmed: 33053279

Auteurs

Zijun Wang (Z)

Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.

Fabian Schmidt (F)

Laboratory of Retrovirology, The Rockefeller University, New York, NY, USA.

Yiska Weisblum (Y)

Laboratory of Retrovirology, The Rockefeller University, New York, NY, USA.

Frauke Muecksch (F)

Laboratory of Retrovirology, The Rockefeller University, New York, NY, USA.

Christopher O Barnes (CO)

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.

Shlomo Finkin (S)

Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.

Dennis Schaefer-Babajew (D)

Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.

Melissa Cipolla (M)

Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.

Christian Gaebler (C)

Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.

Jenna A Lieberman (JA)

Lymphocyte Nuclear Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA.

Thiago Y Oliveira (TY)

Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.

Zhi Yang (Z)

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.

Morgan E Abernathy (ME)

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.

Kathryn E Huey-Tubman (KE)

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.

Arlene Hurley (A)

Hospital Program Direction, The Rockefeller University, New York, NY, USA.

Martina Turroja (M)

Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.

Kamille A West (KA)

Department of Transfusion Medicine, National Institutes of Health Clinical Center, Bethesda, MD, USA.

Kristie Gordon (K)

Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.

Katrina G Millard (KG)

Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.

Victor Ramos (V)

Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.

Justin Da Silva (J)

Laboratory of Retrovirology, The Rockefeller University, New York, NY, USA.

Jianliang Xu (J)

Lymphocyte Nuclear Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA.

Robert A Colbert (RA)

Pediatric Translational Research Branch and Office of the Clinical Director, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA.

Roshni Patel (R)

Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.

Juan Dizon (J)

Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.

Cecille Unson-O'Brien (C)

Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.

Irina Shimeliovich (I)

Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.

Anna Gazumyan (A)

Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.

Marina Caskey (M)

Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.

Pamela J Bjorkman (PJ)

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA. bjorkman@caltech.edu.

Rafael Casellas (R)

Lymphocyte Nuclear Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA. rafael.casellas@nih.gov.
The NIH Regulome Project, National Institutes of Health, Bethesda, MD, USA. rafael.casellas@nih.gov.

Theodora Hatziioannou (T)

Laboratory of Retrovirology, The Rockefeller University, New York, NY, USA. thatziio@rockefeller.edu.

Paul D Bieniasz (PD)

Laboratory of Retrovirology, The Rockefeller University, New York, NY, USA. pbieniasz@rockefeller.edu.
Howard Hughes Medical Institute, The Rockefeller University, New York, NY, USA. pbieniasz@rockefeller.edu.

Michel C Nussenzweig (MC)

Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA. nussen@rockefeller.edu.
Howard Hughes Medical Institute, The Rockefeller University, New York, NY, USA. nussen@rockefeller.edu.

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Classifications MeSH