Revisiting Steroidogenic Pathways in the Human Placenta and Primary Human Trophoblast Cells.
gestation
placenta
steroid metabolism
steroidogenesis
trophoblast
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
08 Feb 2021
08 Feb 2021
Historique:
received:
21
01
2021
revised:
03
02
2021
accepted:
05
02
2021
entrez:
11
2
2021
pubmed:
12
2
2021
medline:
13
4
2021
Statut:
epublish
Résumé
Steroid hormones play a crucial role in supporting a successful pregnancy and ensuring proper fetal development. The placenta is one of the principal tissues in steroid production and metabolism, expressing a vast range of steroidogenic enzymes. Nevertheless, a comprehensive characterization of steroidogenic pathways in the human placenta and potential developmental changes occurring during gestation are poorly understood. Furthermore, the specific contribution of trophoblast cells in steroid release is largely unknown. Thus, this study aimed to (i) identify gestational age-dependent changes in the gene expression of key steroidogenic enzymes and (ii) explore the role of trophoblast cells in steroid biosynthesis and metabolism. Quantitative and Droplet Digital PCR analysis of 12 selected enzymes was carried out in the first trimester (
Identifiants
pubmed: 33567726
pii: ijms22041704
doi: 10.3390/ijms22041704
pmc: PMC7915605
pii:
doi:
Substances chimiques
Steroids
0
Steroid Hydroxylases
EC 1.14.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Swiss National Science Foundation
ID : 310030_149958
Pays : Switzerland
Organisme : Stiftung Lindenhof Bern
ID : 17-15-F
Organisme : Czech Science Foundation
ID : 20/13017S
Organisme : Grant Agency of Charles University
ID : SVV 2020/260414
Références
Acta Physiol (Oxf). 2020 Aug;229(4):e13478
pubmed: 32311818
Endocrinology. 1992 Mar;130(3):1309-17
pubmed: 1537294
Placenta. 2003 Aug;24(7):739-44
pubmed: 12852864
Sci Rep. 2017 Feb 23;7:42941
pubmed: 28230167
Gynecol Endocrinol. 2019 May;35(5):376-384
pubmed: 30793997
Cell Mol Life Sci. 2019 Sep;76(18):3479-3496
pubmed: 31049600
J Clin Endocrinol Metab. 1986 Nov;63(5):1145-50
pubmed: 3489728
Int J Biochem Cell Biol. 2018 Dec;105:35-40
pubmed: 30266525
Endocr Rev. 2004 Dec;25(6):947-70
pubmed: 15583024
Biochemistry. 1991 Mar 26;30(12):3003-10
pubmed: 2007137
Reproduction. 2003 Oct;126(4):425-41
pubmed: 14525525
Genome Biol. 2002 Jun 18;3(7):RESEARCH0034
pubmed: 12184808
Front Pharmacol. 2018 Sep 12;9:1027
pubmed: 30258364
Reprod Biomed Online. 2016 Jan;32(1):14-43
pubmed: 26615903
Int J Mol Sci. 2019 Sep 17;20(18):
pubmed: 31533357
Mol Endocrinol. 1991 Aug;5(8):1147-57
pubmed: 1944309
J Clin Endocrinol Metab. 1972 Dec;35(6):799-808
pubmed: 4634481
Plant Mol Biol. 2012 Jan 31;:
pubmed: 22290409
J Steroid Biochem Mol Biol. 2005 Dec;97(5):401-15
pubmed: 16202579
J Clin Endocrinol Metab. 2011 May;96(5):1385-92
pubmed: 21307141
Am J Med Genet A. 2010 Jan;152A(1):75-83
pubmed: 20014131
Placenta. 2006 Feb-Mar;27(2-3):171-80
pubmed: 16338462
BJOG. 2005 Aug;112(8):1096-101
pubmed: 16045524
Endocrinology. 2017 Feb 1;158(2):199-212
pubmed: 27967205
Am J Hum Genet. 2011 Aug 12;89(2):201-18
pubmed: 21802064
Nucleic Acids Res. 2016 Jul 8;44(W1):W147-53
pubmed: 27190236
Acta Endocrinol (Copenh). 1961 Mar;36:455-61
pubmed: 13762735
Endocrinology. 1986 Apr;118(4):1567-82
pubmed: 3512258
Hum Reprod Update. 2008 Sep-Oct;14(5):497-517
pubmed: 18552168
Placenta. 2010 Nov;31(11):989-96
pubmed: 20850871
J Clin Endocrinol Metab. 1997 Jan;82(1):300-5
pubmed: 8989277
Endocrine. 1997 Jun;6(3):301-7
pubmed: 9368687
J Clin Endocrinol Metab. 1966 Jul;26(7):751-61
pubmed: 4223909
Lancet. 1993 Feb 6;341(8841):355-7
pubmed: 8094124
Placenta. 2018 Dec;72-73:48-52
pubmed: 30501881
Proc Natl Acad Sci U S A. 2017 Jan 10;114(2):E181-E190
pubmed: 28049829
J Immunol Methods. 2004 Mar;286(1-2):21-34
pubmed: 15087219
Front Physiol. 2018 Aug 17;9:1091
pubmed: 30174608
Endocrine. 2012 Dec;42(3):700-7
pubmed: 22638611
PLoS Biol. 2019 Feb 14;17(2):e3000002
pubmed: 30763313
Front Immunol. 2020 Jan 22;10:3017
pubmed: 32038609
Gynecol Endocrinol. 2013 Jul;29(7):657-61
pubmed: 23659736
Int J Dev Biol. 2010;54(2-3):397-408
pubmed: 19876841
J Steroid Biochem Mol Biol. 2015 Jan;145:75-84
pubmed: 25312486
J Clin Endocrinol Metab. 2018 Feb 1;103(2):640-648
pubmed: 29161409
Reprod Biol Endocrinol. 2015 Jul 09;13:71
pubmed: 26156160
Front Cell Dev Biol. 2020 Sep 18;8:574034
pubmed: 33072756
Clin Endocrinol (Oxf). 1997 Feb;46(2):161-6
pubmed: 9135697
Mol Cell Endocrinol. 2011 Aug 6;342(1-2):73-80
pubmed: 21664947
J Clin Endocrinol Metab. 1980 Dec;51(6):1235-8
pubmed: 7440692
Lancet. 1993 Apr 10;341(8850):938-41
pubmed: 8096277