Impact of Type 1 Diabetes in the Developing Brain in Children: A Longitudinal Study.
Journal
Diabetes care
ISSN: 1935-5548
Titre abrégé: Diabetes Care
Pays: United States
ID NLM: 7805975
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
received:
25
08
2020
accepted:
05
01
2021
pubmed:
12
2
2021
medline:
18
9
2021
entrez:
11
2
2021
Statut:
ppublish
Résumé
To assess whether previously observed brain and cognitive differences between children with type 1 diabetes and control subjects without diabetes persist, worsen, or improve as children grow into puberty and whether differences are associated with hyperglycemia. One hundred forty-four children with type 1 diabetes and 72 age-matched control subjects without diabetes (mean ± SD age at baseline 7.0 ± 1.7 years, 46% female) had unsedated MRI and cognitive testing up to four times over 6.4 ± 0.4 (range 5.3-7.8) years; HbA Total brain, gray, and white matter volumes and full-scale and verbal intelligence quotients (IQs) were lower in the diabetes group at 6, 8, 10, and 12 years, with estimated group differences in full-scale IQ of -4.15, -3.81, -3.46, and -3.11, respectively ( Detectable changes in brain volumes and cognitive scores persist over time in children with early-onset type 1 diabetes followed longitudinally; these differences are associated with metrics of hyperglycemia. Whether these changes can be reversed with scrupulous diabetes control requires further study. These longitudinal data support the hypothesis that the brain is a target of diabetes complications in young children.
Identifiants
pubmed: 33568403
pii: dc20-2125
doi: 10.2337/dc20-2125
pmc: PMC7985430
doi:
Substances chimiques
Blood Glucose
0
Banques de données
ClinicalTrials.gov
['NCT02351466']
figshare
['10.2337/figshare.13549097']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
983-992Subventions
Organisme : NICHD NIH HHS
ID : U10 HD041906
Pays : United States
Organisme : NICHD NIH HHS
ID : U10 HD041918
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Organisme : NICHD NIH HHS
ID : U10 HD041915
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001085
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD078463
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR003142
Pays : United States
Organisme : NICHD NIH HHS
ID : U54 HD087011
Pays : United States
Organisme : NICHD NIH HHS
ID : U10 HD056526
Pays : United States
Organisme : NICHD NIH HHS
ID : U10 HD041908
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK045735
Pays : United States
Informations de copyright
© 2021 by the American Diabetes Association.
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