CD8 lymphocyte depletion enhances the latency reversal activity of the SMAC mimetic AZD5582 in ART-suppressed SIV-infected rhesus macaques.


Journal

Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724

Informations de publication

Date de publication:
25 03 2021
Historique:
entrez: 11 2 2021
pubmed: 12 2 2021
medline: 12 2 2021
Statut: ppublish

Résumé

Inducing latency reversal to reveal infected cells to the host immune system represents a potential strategy to cure HIV infection. In separate studies, we have previously shown that CD8

Identifiants

pubmed: 33568515
pii: JVI.01429-20
doi: 10.1128/JVI.01429-20
pmc: PMC8103677
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIH HHS
ID : R01 OD011095
Pays : United States
Organisme : NIAID NIH HHS
ID : P30 AI050409
Pays : United States
Organisme : NCI NIH HHS
ID : 75N91019D00024
Pays : United States
Organisme : NIAID NIH HHS
ID : UM1 AI126619
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI131365
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI028433
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI125064
Pays : United States
Organisme : NIH HHS
ID : U42 OD011023
Pays : United States
Organisme : NIAID NIH HHS
ID : UM1 AI124436
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI152703
Pays : United States
Organisme : NIH HHS
ID : P51 OD011132
Pays : United States

Informations de copyright

Copyright © 2021 Mavigner et al.

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Auteurs

Maud Mavigner (M)

Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, United States of America.
Center for Childhood Infections and Vaccines of Children's Healthcare of Atlanta and Emory University, Atlanta, Georgia, United States of America.

Laura E Liao (LE)

Theoretical Biology and Biophysics Group, MS-K710, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America.

Alyssa D Brooks (AD)

Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, United States of America.

Ruian Ke (R)

Theoretical Biology and Biophysics Group, MS-K710, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America.

Cameron Mattingly (C)

Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, United States of America.

Nils Schoof (N)

Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, United States of America.

Julia McBrien (J)

Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.

Diane Carnathan (D)

Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.

Shan Liang (S)

Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.

Thomas H Vanderford (TH)

Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.

Mirko Paiardini (M)

Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.

Deanna Kulpa (D)

Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.

Jeffrey D Lifson (JD)

AIDS and Cancer Virus Program Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America.

Richard M Dunham (RM)

ViiV Healthcare, Research Triangle Park, North Carolina, United States of America.
University of North Carolina HIV Cure Center and Department of Medicine, UNC Chapel Hill, Chapel Hill, North Carolina, United States of America.

Kirk A Easley (KA)

Department of Biostatistics and Bioinformatics, Emory University Rollins School of Public Health, Atlanta, Georgia, United States of America.

David M Margolis (DM)

University of North Carolina HIV Cure Center and Department of Medicine, UNC Chapel Hill, Chapel Hill, North Carolina, United States of America.

Alan S Perelson (AS)

Theoretical Biology and Biophysics Group, MS-K710, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America.

Guido Silvestri (G)

Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.
Emory Vaccine Center, Emory University, Atlanta, Georgia, United States of America.
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America.

Ann Chahroudi (A)

Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, United States of America ann.m.chahroudi@emory.edu.
Center for Childhood Infections and Vaccines of Children's Healthcare of Atlanta and Emory University, Atlanta, Georgia, United States of America.
Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.

Classifications MeSH