miRNA and mRNA Profiling Links Connexin Deficiency to Deafness via Early Oxidative Damage in the Mouse
connexins
early degeneration
hearing loss
molecular pathway analysis
oxidative stress
post-natal development
systems biology
vascular dysfunction
Journal
Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250
Informations de publication
Date de publication:
2020
2020
Historique:
received:
13
10
2020
accepted:
10
12
2020
entrez:
11
2
2021
pubmed:
12
2
2021
medline:
12
2
2021
Statut:
epublish
Résumé
Pathogenic mutations in the non-syndromic hearing loss and deafness 1 (DFNB1) locus are the primary cause of monogenic inheritance for prelingual hearing loss. To unravel molecular pathways involved in etiopathology and look for early degeneration biomarkers, we used a system biology approach to analyze Cx30
Identifiants
pubmed: 33569381
doi: 10.3389/fcell.2020.616878
pmc: PMC7868390
doi:
Types de publication
Journal Article
Langues
eng
Pagination
616878Informations de copyright
Copyright © 2021 Gentile, Paciello, Zorzi, Spampinato, Guarnaccia, Crispino, Tettey-Matey, Scavizzi, Raspa, Fetoni, Cavallaro and Mammano.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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