Endothelial dysfunction and body mass index: is there a role for plasma peroxynitrite?
body mass index
endothelial dysfunction
endothelial-dependent vascular relaxation
nitrotyrosine
peroxynitrite
Journal
Beni-Suef University journal of basic and applied sciences
ISSN: 2314-8543
Titre abrégé: Beni Suef Univ J Basic Appl Sci
Pays: England
ID NLM: 101758435
Informations de publication
Date de publication:
2021
2021
Historique:
entrez:
11
2
2021
pubmed:
12
2
2021
medline:
12
2
2021
Statut:
ppublish
Résumé
Endothelial function is dependent on the balance between vasoconstrictive and vasodilatory substances. The endothelium ability to produce nitric oxide is one of the most crucial mechanisms in regulating vascular tone. An increase in inducible nitric oxide synthase contributes to endothelial dysfunction in overweight persons, while in underweight persons, oxidative stress contributes to the conversion of nitric oxide to peroxynitrite (measured as nitrotyrosine Nitrotyrosine levels in saline-treated rats were similar among the weight-groups. There was a significant increase in nitrotyrosine levels between saline-treated rats and those treated with the highest lipopolysaccharide doses in each of the weight groups. In response to ACh challenge, R Endothelial dysfunction, observed as an impairment in the ability to reduce tension, is associated with increased plasma peroxynitrite levels across the spectrum of body mass. In higher-BMI rats, an additional role is played by vascular smooth muscle in the causation of endothelial dysfunction.
Sections du résumé
BACKGROUND
BACKGROUND
Endothelial function is dependent on the balance between vasoconstrictive and vasodilatory substances. The endothelium ability to produce nitric oxide is one of the most crucial mechanisms in regulating vascular tone. An increase in inducible nitric oxide synthase contributes to endothelial dysfunction in overweight persons, while in underweight persons, oxidative stress contributes to the conversion of nitric oxide to peroxynitrite (measured as nitrotyrosine
RESULTS
RESULTS
Nitrotyrosine levels in saline-treated rats were similar among the weight-groups. There was a significant increase in nitrotyrosine levels between saline-treated rats and those treated with the highest lipopolysaccharide doses in each of the weight groups. In response to ACh challenge, R
CONCLUSIONS
CONCLUSIONS
Endothelial dysfunction, observed as an impairment in the ability to reduce tension, is associated with increased plasma peroxynitrite levels across the spectrum of body mass. In higher-BMI rats, an additional role is played by vascular smooth muscle in the causation of endothelial dysfunction.
Identifiants
pubmed: 33569505
doi: 10.1186/s43088-020-00092-6
pmc: PMC7872153
mid: NIHMS1667080
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : FIC NIH HHS
ID : D43 TW009744
Pays : United States
Déclaration de conflit d'intérêts
Competing interests The authors declare that they have no competing interests.
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