Increased satellite cell apoptosis in vastus lateralis muscle after anterior cruciate ligament reconstruction.
apoptosis
developmental myosin heavy chain
muscle regeneration
muscular atrophy
quadriceps muscle
satellite cells
Journal
Journal of rehabilitation medicine
ISSN: 1651-2081
Titre abrégé: J Rehabil Med
Pays: Sweden
ID NLM: 101088169
Informations de publication
Date de publication:
17 Feb 2021
17 Feb 2021
Historique:
pubmed:
12
2
2021
medline:
31
3
2021
entrez:
11
2
2021
Statut:
epublish
Résumé
Recovery of the quadriceps femoris muscle after anterior ligament reconstruction is im-paired. The aim of this study was to investigate satellite cell content and function of the vastus lateralis muscle after anterior ligament reconstruction. Biopsies were obtained from the vastus lateralis muscle of 16 recreational athletes immediately before and again 12 weeks after anterior ligament reconstruction. Total satellite cell number (Pax7+), activated (Pax7+/MyoD+), differentiating (Pax7-/MyoD+), and apoptotic (Pax7+/TUNEL+) satellite cells, myofibers expressing myosin heavy chain (MHC) I and II, and neonatal MHC (MHCneo) were determined immunohistochemically. After anterior ligament reconstruction, the number of apoptotic satellite cells was significantly (p = 0.019) increased, concomitant with a significant (p < 0.001) decrease in total satellite cell number, with no change in activated and differentiating satellite cell number. MHCneo+ myofibers tended towards an increase. Satellite cell apoptosis and the reduction in the satellite cell pool might provide an explanation for prolonged quadriceps muscle atrophy after anterior ligament reconstruction.
Identifiants
pubmed: 33569607
doi: 10.2340/16501977-2794
pmc: PMC8814877
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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