Hepatic injury and COVID-19: pathogenic mechanisms or epiphenomena?

Ampuero J et al. analyzed the relationship between liver injury and clinical progression of the disease in a meta-analysis of over 5,000 COVID-19 patients. The authors reported an association between increased aspartate aminotransferase (AST), alanine aminotransferase (ALT) and bilirubin levels with mortality, admission to Intensive Care and the development of complications, respectively.