Suzuki Coupling of Protected Aryl Diazonium Ions: Expanding the Knowledge of Triazabutadiene Compatible Reactions.
Journal
Organic letters
ISSN: 1523-7052
Titre abrégé: Org Lett
Pays: United States
ID NLM: 100890393
Informations de publication
Date de publication:
05 03 2021
05 03 2021
Historique:
pubmed:
12
2
2021
medline:
5
10
2021
entrez:
11
2
2021
Statut:
ppublish
Résumé
Aryl diazonium ions are important in synthesis and chemical biology, and the acid-labile triazabutadiene can protect this handle for future use. We report a Suzuki coupling strategy that is compatible with the triazabutadiene scaffold, expanding the scope of synthetically available triazabutadienes. Shown herein, the triazabutadiene scaffold remains intact and reactive after coupling, as demonstrated by releasing the aryl diazonium ion to label a tyrosine-rich model protein.
Identifiants
pubmed: 33570414
doi: 10.1021/acs.orglett.1c00257
pmc: PMC7955896
mid: NIHMS1675740
doi:
Substances chimiques
Diazonium Compounds
0
Ions
0
Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
1851-1855Subventions
Organisme : NIGMS NIH HHS
ID : R35 GM128624
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM008804
Pays : United States
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