Histone H3 methyltransferase Ezh2 promotes white adipocytes but inhibits brown and beige adipocyte differentiation in mice.
Beige adipocytes
Brown adipocytes
Differentiation
Ezh2
H3K27me3
White adipocytes
Journal
Biochimica et biophysica acta. Molecular and cell biology of lipids
ISSN: 1879-2618
Titre abrégé: Biochim Biophys Acta Mol Cell Biol Lipids
Pays: Netherlands
ID NLM: 101731727
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
received:
19
07
2020
revised:
18
01
2021
accepted:
04
02
2021
pubmed:
12
2
2021
medline:
18
9
2021
entrez:
11
2
2021
Statut:
ppublish
Résumé
Obesity is a disease characterized by imbalance between energy intake and expenditure, excessive energy store in white adipocytes, but brown and beige adipocytes consume energy to relieve obesity. In this study, we want to explore the role of the histone H3 methyltransferase Ezh2 in the differentiation of white, brown and beige adipocytes with Ezh2 conditional knockout mice (Ezh2
Identifiants
pubmed: 33571671
pii: S1388-1981(21)00027-5
doi: 10.1016/j.bbalip.2021.158901
pii:
doi:
Substances chimiques
Histone Methyltransferases
EC 2.1.1.-
Enhancer of Zeste Homolog 2 Protein
EC 2.1.1.43
Ezh2 protein, mouse
EC 2.1.1.43
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
158901Informations de copyright
Copyright © 2021 Elsevier B.V. All rights reserved.