Different Roles of Mitochondria in Cell Death and Inflammation: Focusing on Mitochondrial Quality Control in Ischemic Stroke and Reperfusion.
cell death
inflammation
ischemic reperfusion
ischemic stroke
mitochondrial fission
mitochondrial fusion
mitochondrial transfer
mitophagy
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
09 Feb 2021
09 Feb 2021
Historique:
received:
04
01
2021
revised:
03
02
2021
accepted:
04
02
2021
entrez:
12
2
2021
pubmed:
13
2
2021
medline:
13
2
2021
Statut:
epublish
Résumé
Mitochondrial dysfunctions are among the main hallmarks of several brain diseases, including ischemic stroke. An insufficient supply of oxygen and glucose in brain cells, primarily neurons, triggers a cascade of events in which mitochondria are the leading characters. Mitochondrial calcium overload, reactive oxygen species (ROS) overproduction, mitochondrial permeability transition pore (mPTP) opening, and damage-associated molecular pattern (DAMP) release place mitochondria in the center of an intricate series of chance interactions. Depending on the degree to which mitochondria are affected, they promote different pathways, ranging from inflammatory response pathways to cell death pathways. In this review, we will explore the principal mitochondrial molecular mechanisms compromised during ischemic and reperfusion injury, and we will delineate potential neuroprotective strategies targeting mitochondrial dysfunction and mitochondrial homeostasis.
Identifiants
pubmed: 33572080
pii: biomedicines9020169
doi: 10.3390/biomedicines9020169
pmc: PMC7914955
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : European Research Council
ID : 853057-InflaPML
Pays : International
Organisme : Associazione Italiana per la Ricerca sul Cancro
ID : IG-19803
Organisme : Associazione Italiana per la Ricerca sul Cancro
ID : IG-23670
Organisme : Progetti di Rilevante Interesse Nazionale
ID : PRIN20177E9EPY
Organisme : Progetti di Rilevante Interesse Nazionale
ID : PRIN2017E5L5P3
Organisme : Italian Ministry of Health
ID : GR-2013-02356747
Organisme : Bundesministerium für Bildung und Forschung
ID : 13XP5060B
Organisme : German Research Foundation (DFG FOR 2879)
ID : LU 1924/1-1
Organisme : German Research Foundation (DFG FOR 2879)
ID : MA 4375/6-1
Organisme : Fondazione Umberto Veronesi
ID : Grant research Fellowship 2020
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