TLR-Mediated Cytokine Gene Expression in Chicken Peripheral Blood Mononuclear Cells as a Measure to Characterize Immunobiotics.


Journal

Genes
ISSN: 2073-4425
Titre abrégé: Genes (Basel)
Pays: Switzerland
ID NLM: 101551097

Informations de publication

Date de publication:
29 01 2021
Historique:
received: 17 12 2020
revised: 22 01 2021
accepted: 26 01 2021
entrez: 12 2 2021
pubmed: 13 2 2021
medline: 23 7 2021
Statut: epublish

Résumé

Immunobiotics are probiotics that promote intestinal health by modulating immune responses. Immunobiotics are recognized by Toll-like receptors (TLRs) and activate cytokine gene expression. This study aimed to characterize cytokine gene expression in the chicken peripheral blood mononuclear cells (PBMC) stimulated with purified TLR ligands and live probiotics. PBMC were isolated from the whole blood. PBMC were stimulated with: lipopolysaccharide (LPS), CpG ODN, Pam3CSK4, Zymosan, galactooligosaccharides (GOS),

Identifiants

pubmed: 33572768
pii: genes12020195
doi: 10.3390/genes12020195
pmc: PMC7912573
pii:
doi:

Substances chimiques

Cytokines 0
Lipopeptides 0
Lipopolysaccharides 0
Oligosaccharides 0
Pam(3)CSK(4) peptide 0
Toll-Like Receptors 0
Zymosan 9010-72-4

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

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Auteurs

Anna Slawinska (A)

Department of Animal Biotechnology and Genetics, UTP University of Science and Technology, 85-084 Bydgoszcz, Poland.

Aleksandra Dunislawska (A)

Department of Animal Biotechnology and Genetics, UTP University of Science and Technology, 85-084 Bydgoszcz, Poland.

Arkadiusz Plowiec (A)

Department of Animal Biotechnology and Genetics, UTP University of Science and Technology, 85-084 Bydgoszcz, Poland.

José Gonçalves (J)

Department of Animal Biotechnology and Genetics, UTP University of Science and Technology, 85-084 Bydgoszcz, Poland.

Maria Siwek (M)

Department of Animal Biotechnology and Genetics, UTP University of Science and Technology, 85-084 Bydgoszcz, Poland.

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Classifications MeSH