Orientation of Antigen Display on Self-Assembling Protein Nanoparticles Influences Immunogenicity.
PfCelTOS
PfMSP119
display
multi-stage
self-assembling protein nanoparticles
vaccine
Journal
Vaccines
ISSN: 2076-393X
Titre abrégé: Vaccines (Basel)
Pays: Switzerland
ID NLM: 101629355
Informations de publication
Date de publication:
29 Jan 2021
29 Jan 2021
Historique:
received:
07
01
2021
revised:
22
01
2021
accepted:
26
01
2021
entrez:
12
2
2021
pubmed:
13
2
2021
medline:
13
2
2021
Statut:
epublish
Résumé
Self-assembling protein nanoparticles (SAPN) serve as a repetitive antigen delivery platform with high-density epitope display; however, antigen characteristics such as size and epitope presentation can influence the immunogenicity of the assembled particle and are aspects to consider for a rationally designed effective vaccine. Here, we characterize the folding and immunogenicity of heterogeneous antigen display by integrating (a) dual-stage antigen SAPN presenting the
Identifiants
pubmed: 33572803
pii: vaccines9020103
doi: 10.3390/vaccines9020103
pmc: PMC7911071
pii:
doi:
Types de publication
Journal Article
Langues
eng
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