Protein Export via the Type III Secretion System of the Bacterial Flagellum.
Adenosine Triphosphatases
/ metabolism
Bacterial Proteins
/ metabolism
Cell Membrane
/ metabolism
Cytoplasm
/ metabolism
Flagella
/ metabolism
Gram-Negative Bacteria
/ metabolism
Hydrolysis
Membrane Proteins
/ metabolism
Protein Denaturation
Protein Transport
Substrate Specificity
Type III Secretion Systems
/ metabolism
ATPase
bacterial flagellum
flagellar assembly
proton motive force
secretion model
type III protein export
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
29 01 2021
29 01 2021
Historique:
received:
30
12
2020
revised:
25
01
2021
accepted:
26
01
2021
entrez:
12
2
2021
pubmed:
13
2
2021
medline:
24
7
2021
Statut:
epublish
Résumé
The bacterial flagellum and the related virulence-associated injectisome system of pathogenic bacteria utilize a type III secretion system (T3SS) to export substrate proteins across the inner membrane in a proton motive force-dependent manner. The T3SS is composed of an export gate (FliPQR/FlhA/FlhB) located in the flagellar basal body and an associated soluble ATPase complex in the cytoplasm (FliHIJ). Here, we summarise recent insights into the structure, assembly and protein secretion mechanisms of the T3SS with a focus on energy transduction and protein transport across the cytoplasmic membrane.
Identifiants
pubmed: 33572887
pii: biom11020186
doi: 10.3390/biom11020186
pmc: PMC7911332
pii:
doi:
Substances chimiques
Bacterial Proteins
0
FlhA protein, Bacteria
0
Membrane Proteins
0
Type III Secretion Systems
0
Adenosine Triphosphatases
EC 3.6.1.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
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