The P.E.A.N.U.T. Method: Update on an Integrative System Approach for the Treatment of Chronic Otitis Media with Effusion and Adenoid Hypertrophy in Children.
adenoid hypertrophy
analgesics
antibiotics
children
chronic otitis media with effusion
integrative therapy
surgical interventions
Journal
Antibiotics (Basel, Switzerland)
ISSN: 2079-6382
Titre abrégé: Antibiotics (Basel)
Pays: Switzerland
ID NLM: 101637404
Informations de publication
Date de publication:
30 Jan 2021
30 Jan 2021
Historique:
received:
05
12
2020
revised:
18
01
2021
accepted:
26
01
2021
entrez:
12
2
2021
pubmed:
13
2
2021
medline:
13
2
2021
Statut:
epublish
Résumé
Based on our previous single-center study on optimization of treatment of chronic otitis media with effusion (COME) and adenoid hypertrophy (AH) in children using a noninvasive system approach to lower the necessity of antibiotics, analgesic use, and surgical interventions, we proceeded to perform a multicenter investigation in an outpatient setting. The purpose of the previous prospective study in 2013-2015 was to compare outcomes in the treatment of COME and AH using the noninvasive multimodal integrative method (IM) versus conventional treatment practice (COM). In this paper, we retrospectively analyze the data of patients treated with the integrative method between 2017 and 2020 in a multicenter setting and compared the outcomes with data from 2013-2015 in order to evaluate generalizability. In both periods, all eligible and willing participants were included and treated with the IM protocol under real-life conditions. The treatment involved pneumatization exercises, education, an antiallergic diet, nasal hygiene, useful constitutional therapy, and thermal interventions (P.E.A.N.U.T.). A total of 48 versus 28 patients, aged 1-8, were assessed, presenting with COME and AH, with moderate to severe hearing impairment at entry. The significant improvement found in both audiometric measures (intact hearing) and tympanometric measures (normal A-type curve) was similar in both datasets with respect to conventional treatment. The new data confirms that the P.E.A.N.U.T. method results in a significant reduction of antibiotics, analgesic use, and surgical interventions. In this multicenter trial, we confirm the effectiveness of the noninvasive system approach for the treatment of COME in lowering the need for antibiotics and analgesic use and elective surgery. This could be especially important with respect to a generally observed increase in antibiotic resistance. The method is easy to perform in different clinical settings and is effective, safe, and well-tolerated.
Sections du résumé
BACKGROUND AND OBJECTIVES
OBJECTIVE
Based on our previous single-center study on optimization of treatment of chronic otitis media with effusion (COME) and adenoid hypertrophy (AH) in children using a noninvasive system approach to lower the necessity of antibiotics, analgesic use, and surgical interventions, we proceeded to perform a multicenter investigation in an outpatient setting. The purpose of the previous prospective study in 2013-2015 was to compare outcomes in the treatment of COME and AH using the noninvasive multimodal integrative method (IM) versus conventional treatment practice (COM).
MATERIALS AND METHODS
METHODS
In this paper, we retrospectively analyze the data of patients treated with the integrative method between 2017 and 2020 in a multicenter setting and compared the outcomes with data from 2013-2015 in order to evaluate generalizability. In both periods, all eligible and willing participants were included and treated with the IM protocol under real-life conditions. The treatment involved pneumatization exercises, education, an antiallergic diet, nasal hygiene, useful constitutional therapy, and thermal interventions (P.E.A.N.U.T.). A total of 48 versus 28 patients, aged 1-8, were assessed, presenting with COME and AH, with moderate to severe hearing impairment at entry.
RESULTS
RESULTS
The significant improvement found in both audiometric measures (intact hearing) and tympanometric measures (normal A-type curve) was similar in both datasets with respect to conventional treatment. The new data confirms that the P.E.A.N.U.T. method results in a significant reduction of antibiotics, analgesic use, and surgical interventions.
CONCLUSION
CONCLUSIONS
In this multicenter trial, we confirm the effectiveness of the noninvasive system approach for the treatment of COME in lowering the need for antibiotics and analgesic use and elective surgery. This could be especially important with respect to a generally observed increase in antibiotic resistance. The method is easy to perform in different clinical settings and is effective, safe, and well-tolerated.
Identifiants
pubmed: 33573118
pii: antibiotics10020134
doi: 10.3390/antibiotics10020134
pmc: PMC7911258
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Software AG - Stiftung
ID : P126666
Références
Forsch Komplementmed. 2007 Aug;14(4):207-15
pubmed: 17848797
J Otol. 2019 Jun;14(2):33-39
pubmed: 31223299
JAMA. 2009 Aug 19;302(7):758-66
pubmed: 19690308
Laryngoscope. 2020 Mar;130(3):806-811
pubmed: 31021431
Clin Microbiol Rev. 2002 Apr;15(2):167-93
pubmed: 11932229
J Agric Food Chem. 2007 Feb 7;55(3):963-9
pubmed: 17263500
Phytother Res. 2016 Sep;30(9):1481-6
pubmed: 27282490
J Otol. 2019 Sep;14(3):101-105
pubmed: 31467507
Pediatrics. 2014 Feb;133(2):296-311
pubmed: 24394689
Laryngorhinootologie. 1995 Jun;74(6):352-4
pubmed: 7662078
Evid Based Complement Alternat Med. 2014;2014:243801
pubmed: 25505919
Front Genet. 2019 Nov 19;10:1176
pubmed: 31803245
Evid Based Complement Alternat Med. 2019 Feb 3;2019:5365608
pubmed: 30854009
Planta Med. 2012 Mar;78(4):334-40
pubmed: 22193979
Mediators Inflamm. 2012;2012:109829
pubmed: 22315506
Laryngoscope. 2003 Oct;113(10):1645-57
pubmed: 14520089
ISRN Allergy. 2011 Jul 18;2011:836051
pubmed: 23724234
Cochrane Database Syst Rev. 2016 Jun 12;(6):CD009163
pubmed: 27290722
Int J Pediatr Otorhinolaryngol. 2013 Jun;77(6):926-31
pubmed: 23562352
Int J Pediatr Otorhinolaryngol. 2014 Aug;78(8):1298-305
pubmed: 24882460
Altern Med Rev. 2003 Feb;8(1):28-42
pubmed: 12611559
Ugeskr Laeger. 1991 Oct 21;153(43):3008-9
pubmed: 1801386
CMAJ. 2015 Sep 22;187(13):961-969
pubmed: 26216608
Eur Arch Otorhinolaryngol. 2020 May;277(5):1281-1287
pubmed: 32002612
Phytother Res. 2016 Nov;30(11):1745-1764
pubmed: 27528198
Eur Arch Otorhinolaryngol. 2019 Aug;276(8):2125-2131
pubmed: 31127413
Wien Klin Wochenschr. 2005 Apr;117(7-8):256-68
pubmed: 15926617
Pediatrics. 2003 May;111(5 Pt 1):e574-9
pubmed: 12728112
Phytomedicine. 2011 Jun 15;18(8-9):760-8
pubmed: 21256726
Complement Ther Med. 2018 Dec;41:287-294
pubmed: 30477855
Forsch Komplementmed. 2016;23(4):231-9
pubmed: 27607438
Clin Otolaryngol Allied Sci. 1993 Jun;18(3):188-92
pubmed: 8365006
Laryngoscope. 2016 Dec;126(12):2844-2851
pubmed: 27335217
J Korean Med Sci. 2012 Aug;27(8):835-48
pubmed: 22876048
PLoS One. 2014 Jan 23;9(1):e86397
pubmed: 24466073
Otolaryngol Head Neck Surg. 2016 Feb;154(2):201-14
pubmed: 26833645
Mediators Inflamm. 2008;2008:496467
pubmed: 19079587
Acta Otolaryngol. 1999;119(8):867-73
pubmed: 10728925