Pseudo-Dipeptide Bearing α,α-Difluoromethyl Ketone Moiety as Electrophilic Warhead with Activity against Coronaviruses.
A549 Cells
Antiviral Agents
/ chemistry
Binding Sites
COVID-19
/ pathology
Cell Line
Coronavirus 229E, Human
/ metabolism
Coronavirus M Proteins
/ chemistry
Dipeptides
/ chemistry
Humans
Ketones
/ chemistry
Molecular Docking Simulation
Molecular Dynamics Simulation
SARS-CoV-2
/ isolation & purification
Thermodynamics
Viral Matrix Proteins
/ chemistry
Virus Replication
/ drug effects
SARS-CoV-2 Mpro
coronavirus
cysteine proteases
difluoromethyl ketone
hCoV-229E
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
30 Jan 2021
30 Jan 2021
Historique:
received:
22
12
2020
accepted:
26
01
2021
entrez:
12
2
2021
pubmed:
13
2
2021
medline:
20
2
2021
Statut:
epublish
Résumé
The synthesis of α-fluorinated methyl ketones has always been challenging. New methods based on the homologation chemistry via nucleophilic halocarbenoid transfer, carried out recently in our labs, allowed us to design and synthesize a target-directed dipeptidyl α,α-difluoromethyl ketone (DFMK)
Identifiants
pubmed: 33573283
pii: ijms22031398
doi: 10.3390/ijms22031398
pmc: PMC7866854
pii:
doi:
Substances chimiques
Antiviral Agents
0
Coronavirus M Proteins
0
Dipeptides
0
Ketones
0
Viral Matrix Proteins
0
membrane protein, SARS-CoV-2
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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